1-Benzyl-6-[5-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-phenyl]-1,7-dihydro-imidazo[4,5-g]quinazolin-8-one

ID: ALA283122

Chembl Id: CHEMBL283122

PubChem CID: 135485820

Max Phase: Preclinical

Molecular Formula: C30H32N6O4S

Molecular Weight: 572.69

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  CCCOc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1-c1nc(O)c2cc3c(cc2n1)ncn3Cc1ccccc1

Standard InChI:  InChI=1S/C30H32N6O4S/c1-3-15-40-28-10-9-22(41(38,39)36-13-11-34(2)12-14-36)16-24(28)29-32-25-18-26-27(17-23(25)30(37)33-29)35(20-31-26)19-21-7-5-4-6-8-21/h4-10,16-18,20H,3,11-15,19H2,1-2H3,(H,32,33,37)

Standard InChI Key:  SJTYUWYMRLXRKL-UHFFFAOYSA-N

Alternative Forms

  1. Parent:

    ALA283122

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Associated Targets(Human)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE5A Tclin Phosphodiesterase 3 and 5 (PDE3 and PDE5) (91 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE5A Tclin Phosphodiesterase 4 and 5 (PDE4 and PDE5) (47 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 572.69Molecular Weight (Monoisotopic): 572.2206AlogP: 4.13#Rotatable Bonds: 8
Polar Surface Area: 113.68Molecular Species: NEUTRALHBA: 9HBD: 1
#RO5 Violations: 1HBA (Lipinski): 10HBD (Lipinski): 1#RO5 Violations (Lipinski): 1
CX Acidic pKa: 12.39CX Basic pKa: 5.99CX LogP: 5.01CX LogD: 4.99
Aromatic Rings: 5Heavy Atoms: 41QED Weighted: 0.30Np Likeness Score: -1.58

References

1. Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE..  (2000)  N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.,  43  (7): [PMID:10753463] [10.1021/jm000081+]
2. Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE..  (2000)  Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors.,  43  (26): [PMID:11150175] [10.1021/jm000336j]

Source