1. Monn JA, Thurkauf A, Mattson MV, Jacobson AE, Rice KC.. (1990) Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site., 33 (3): [PMID:2155320] [10.1021/jm00165a029] |
2. Monn JA, Thurkauf A, Mattson MV, Jacobson AE, Rice KC.. (1990) Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site., 33 (3): [PMID:2155320] [10.1021/jm00165a029] |
3. Monn JA, Thurkauf A, Mattson MV, Jacobson AE, Rice KC.. (1990) Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site., 33 (3): [PMID:2155320] [10.1021/jm00165a029] |
4. Gray NM, Cheng BK, Mick SJ, Lair CM, Contreras PC.. (1989) Phencyclidine-like effects of tetrahydroisoquinolines and related compounds., 32 (6): [PMID:2542555] [10.1021/jm00126a016] |
5. Leeson PD, Carling RW, James K, Smith JD, Moore KW, Wong EH, Baker R.. (1990) Role of hydrogen bonding in ligand interaction with the N-methyl-D-aspartate receptor ion channel., 33 (5): [PMID:1691788] [10.1021/jm00167a005] |
6. Leeson PD, Carling RW, James K, Smith JD, Moore KW, Wong EH, Baker R.. (1990) Role of hydrogen bonding in ligand interaction with the N-methyl-D-aspartate receptor ion channel., 33 (5): [PMID:1691788] [10.1021/jm00167a005] |
7. Leeson PD, Carling RW, James K, Smith JD, Moore KW, Wong EH, Baker R.. (1990) Role of hydrogen bonding in ligand interaction with the N-methyl-D-aspartate receptor ion channel., 33 (5): [PMID:1691788] [10.1021/jm00167a005] |
8. Dumont F, Sultana A, Waterhouse RN.. (2002) Synthesis and in vitro evaluation of N,N'-diphenyl and N-naphthyl-N'-phenylguanidines as N-methyl-D-aspartate receptor ion-channel ligands., 12 (12): [PMID:12039567] [10.1016/s0960-894x(02)00235-4] |
9. Chen C, Kozikowski AP, Wood PL, Reynolds IJ, Ball RG, Pang YP.. (1992) Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency., 35 (9): [PMID:1315871] [10.1021/jm00087a020] |
10. Kozikowski AP, Steensma D, Araldi GL, Tückmantel W, Wang S, Pshenichkin S, Surina E, Wroblewski JT.. (1998) Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist., 41 (10): [PMID:9572889] [10.1021/jm970719q] |
11. Kumar V, Carabateas PM, Dority JA, Earley WG, Mallamo JP, Subramanyam C, Aimone LD, Ault B, DeHaven Hudkins DL, Miller MS.. (1995) Novel NMDA antagonists: replacement of the pyridinium ring of 6,11-ethanobenzo[b]quinolizinium cations with heteroisoquinolinium cations., 38 (10): [PMID:7752207] [10.1021/jm00010a028] |
12. Moe ST, Shimizu SM, Smith DL, Van Wagenen BC, DelMar EG, Balandrin MF, Chien Y, Raszkiewicz JL, Artman LD, Mueller AL, Lobkovsky E, Clardy J.. (1999) Synthesis, biological activity, and absolute stereochemical assignment of NPS 1392: a potent and stereoselective NMDA receptor antagonist., 9 (14): [PMID:10450953] [10.1016/s0960-894x(99)00317-0] |
13. Gee KR, Barmettler P, Rhodes MR, McBurney RN, Reddy NL, Hu LY, Cotter RE, Hamilton PN, Weber E, Keana JF.. (1993) 10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands., 36 (14): [PMID:8101572] [10.1021/jm00066a002] |
14. Bigge CF, Malone TC, Hays SJ, Johnson G, Novak PM, Lescosky LJ, Retz DM, Ortwine DF, Probert AW, Coughenour LL.. (1993) Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex., 36 (14): [PMID:8336337] [10.1021/jm00066a007] |
15. Goodnow RA, Bukownik R, Nakanishi K, Usherwood PN, Eldefrawi AT, Anis NA, Eldefrawi ME.. (1991) Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranes., 34 (8): [PMID:1652018] [10.1021/jm00112a012] |
16. Moe ST, Smith DL, DelMar EG, Shimizu SM, Van Wagenen BC, Balandrin MF, Chien YE, Raszkiewicz JL, Artman LD, White HS, Mueller AL.. (2000) Chiral synthesis and pharmacological evaluation of NPS 1407: a potent, stereoselective NMDA receptor antagonist., 10 (21): [PMID:11078190] [10.1016/s0960-894x(00)00470-4] |
17. Subramanyam C, Mallamo JP, Pilling GM, Earley WG, Carabateas PM, Wetzel JR, DeHaven-Hudkins D, Allen T, Kullnig RK.. (1995) Synthesis and evaluation of 6,11-ethanohexahydrobenzo[b]quinolizidines: a new class of noncompetitive N-methyl-D-aspartate antagonists., 38 (13): [PMID:7608913] [10.1021/jm00013a025] |
18. Linders JT, Monn JA, Mattson MV, George C, Jacobson AE, Rice KC.. (1993) Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site., 36 (17): [PMID:8355251] [10.1021/jm00069a008] |
19. Subramanyam C, Mallamo JP, Dority JA, Earley WG, Kumar V, Aimone LD, Ault B, Miller MS, Luttinger DA, DeHaven-Hudkins DL.. (1995) Discovery of 6,11-ethano-12,12-diaryl-6,11-dihydrobenzo[b]quinolizinium cations, a novel class of N-methyl-D-aspartate antagonists., 38 (1): [PMID:7837234] [10.1021/jm00001a006] |
20. Jimonet P, Audiau F, Barreau M, Blanchard JC, Boireau A, Bour Y, Coléno MA, Doble A, Doerflinger G, Huu CD, Donat MH, Duchesne JM, Ganil P, Guérémy C, Honor E, Just B, Kerphirique R, Gontier S, Hubert P, Laduron PM, Le Blevec J, Meunier M, Miquet JM, Nemecek C, Mignani S.. (1999) Riluzole series. Synthesis and in vivo "antiglutamate" activity of 6-substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines., 42 (15): [PMID:10425092] [10.1021/jm980202u] |
21. Martin LL, Lee GE, Lee TB, Rush DK, Wilmot CA, Paulus E, Elben U, Grome JJ, Porsche-Wiebking E, Rudolphi KA.. (1994) Synthesis, resolution, and SAR of (+/-)-2-amino-N-methyl-alpha-(3-methyl-2-thienyl)benzeneethanamine++ + and related analogs as noncompetitive NMDA antagonists with neuroprotective properties., 37 (19): [PMID:7932522] [10.1021/jm00045a004] |
22. Earley WG, Kumar V, Mallamo JP, Subramanyam C, Dority JA, Miller MS, DeHaven-Hudkins DL, Aimone LD, Kelly MD, Ault B.. (1995) Novel benzo[b]quinolizinium cations as uncompetitive N-methyl-D-aspartic acid (NMDA) antagonists: the relationship between log D and agonist independent (closed) NMDA channel block., 38 (18): [PMID:7658445] [10.1021/jm00018a018] |
23. Reuman M, Mallamo JP, DeHaven-Hudkins DL. (1995) Synthesis and binding affinity of 2,3,3a,4,9,9a-hexahydro-9,4-(iminomethano)-1H-benz[f]indenes. Ligands for the PCP site of the NMDA receptor, 5 (4): [10.1016/0960-894X(95)00038-U] |
24. Kroemer RT, Koutsilieri E, Hecht P, Liedl KR, Riederer P, Kornhuber J.. (1998) Quantitative analysis of the structural requirements for blockade of the N-methyl-D-aspartate receptor at the phencyclidine binding site., 41 (3): [PMID:9464369] [10.1021/jm9704412] |
25. Kroemer RT, Koutsilieri E, Hecht P, Liedl KR, Riederer P, Kornhuber J.. (1998) Quantitative analysis of the structural requirements for blockade of the N-methyl-D-aspartate receptor at the phencyclidine binding site., 41 (3): [PMID:9464369] [10.1021/jm9704412] |
26. Newman AH, Bevan K, Bowery N, Tortella FC.. (1992) Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents., 35 (22): [PMID:1433216] [10.1021/jm00100a019] |
27. Hu LY, Guo J, Magar SS, Fischer JB, Burke-Howie KJ, Durant GJ.. (1997) Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers., 40 (26): [PMID:9435897] [10.1021/jm970459c] |
28. Kimes AS, Wilson AA, Scheffel U, Campbell BG, London ED.. (1992) Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites., 35 (25): [PMID:1469697] [10.1021/jm00103a005] |
29. Moriarty RM, Enache LA, Zhao L, Gilardi R, Mattson MV, Prakash O.. (1998) Rigid phencyclidine analogues. Binding to the phencyclidine and sigma 1 receptors., 41 (4): [PMID:9484497] [10.1021/jm970059p] |
30. Shuto S, Ono S, Hase Y, Ueno Y, Noguchi T, Yoshii K, Matsuda A.. (1996) Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist., 39 (24): [PMID:8941398] [10.1021/jm960495w] |
31. Malone TC, Ortwine DF, Johnson G, Probert AW. (1993) Synthesis and biological activity of conformationally constrained 4a-phenanthreneamine derivatives as noncompetitive NMDA antagonists, 3 (1): [10.1016/S0960-894X(00)80090-6] |
32. Hays SJ, Novak PM, Ortwine DF, Bigge CF, Colbry NL, Johnson G, Lescosky LJ, Malone TC, Michael A, Reily MD.. (1993) Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor., 36 (6): [PMID:8459395] [10.1021/jm00058a002] |
33. Carling RW, Leeson PD, Moseley AM, Smith JD, Saywell K, Tricklebank MD, Kemp JA, Marshall GR, Foster AC, Grimwood S. (1993) Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines., 3 (1): [10.1016/S0960-894X(00)80093-1] |
34. Thompson WJ, Anderson PS, Britcher SF, Lyle TA, Thies JE, Magill CA, Varga SL, Schwering JE, Lyle PA, Christy ME.. (1990) Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists., 33 (2): [PMID:1688947] [10.1021/jm00164a052] |
35. Thompson WJ, Anderson PS, Britcher SF, Lyle TA, Thies JE, Magill CA, Varga SL, Schwering JE, Lyle PA, Christy ME.. (1990) Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists., 33 (2): [PMID:1688947] [10.1021/jm00164a052] |
36. Thompson WJ, Anderson PS, Britcher SF, Lyle TA, Thies JE, Magill CA, Varga SL, Schwering JE, Lyle PA, Christy ME.. (1990) Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists., 33 (2): [PMID:1688947] [10.1021/jm00164a052] |
37. Elger B, Huth A, Neuhaus R, Ottow E, Schneider H, Seilheimer B, Turski L.. (2005) Novel alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration., 48 (14): [PMID:15999999] [10.1021/jm0580003] |
38. Minetti P, Tinti MO, Carminati P, Castorina M, Di Cesare MA, Di Serio S, Gallo G, Ghirardi O, Giorgi F, Giorgi L, Piersanti G, Bartoccini F, Tarzia G.. (2005) 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization., 48 (22): [PMID:16250647] [10.1021/jm058018d] |
39. Di Fabio R, Alvaro G, Bertani B, Donati D, Pizzi DM, Gentile G, Pentassuglia G, Giacobbe S, Spada S, Ratti E, Corsi M, Quartaroli M, Barnaby RJ, Vitulli G.. (2007) Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain., 17 (5): [PMID:17218099] [10.1016/j.bmcl.2006.12.022] |
40. Geldenhuys WJ, Malan SF, Bloomquist JR, Van der Schyf CJ.. (2007) Structure-activity relationships of pentacycloundecylamines at the N-methyl-d-aspartate receptor., 15 (3): [PMID:17157509] [10.1016/j.bmc.2006.09.060] |
41. Terauchi T, Asai N, Doko T, Taguchi R, Takenaka O, Sakurai H, Yonaga M, Kimura T, Kajiwara A, Niidome T, Kume T, Akaike A, Sugimoto H.. (2007) Synthesis and pharmacological profile of serofendic acids A and B., 15 (22): [PMID:17804246] [10.1016/j.bmc.2007.07.037] |
42. Kaczor AA, Kijkowska-Murak UA, Matosiuk D.. (2008) Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor., 51 (13): [PMID:18540667] [10.1021/jm7011694] |
43. Tahirovic YA, Geballe M, Gruszecka-Kowalik E, Myers SJ, Lyuboslavsky P, Le P, French A, Irier H, Choi WB, Easterling K, Yuan H, Wilson LJ, Kotloski R, McNamara JO, Dingledine R, Liotta DC, Traynelis SF, Snyder JP.. (2008) Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists., 51 (18): [PMID:18800760] [10.1021/jm8002153] |
44. Berger ML, Schweifer A, Rebernik P, Hammerschmidt F.. (2009) NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds., 17 (9): [PMID:19345586] [10.1016/j.bmc.2009.03.025] |
45. Berger ML, Schweifer A, Rebernik P, Hammerschmidt F.. (2009) NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds., 17 (9): [PMID:19345586] [10.1016/j.bmc.2009.03.025] |
46. Kang SY, Lee KY, Sung SH, Kim YC.. (2005) Four new neuroprotective dihydropyranocoumarins from Angelica gigas., 68 (1): [PMID:15679317] [10.1021/np049705v] |
47. Both FL, Meneghini L, Kerber VA, Henriques AT, Elisabetsky E.. (2005) Psychopharmacological profile of the alkaloid psychollatine as a 5HT2A/C serotonin modulator., 68 (3): [PMID:15787439] [10.1021/np049695y] |
48. Geiger C, Zelenka C, Lehmkuhl K, Schepmann D, Englberger W, Wünsch B.. (2010) Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives., 53 (10): [PMID:20441176] [10.1021/jm100182p] |
49. Rook Y, Schmidtke KU, Gaube F, Schepmann D, Wünsch B, Heilmann J, Lehmann J, Winckler T.. (2010) Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., 53 (9): [PMID:20361801] [10.1021/jm1000024] |
50. Banerjee A, Schepmann D, Wünsch B.. (2010) Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues., 18 (11): [PMID:20451396] [10.1016/j.bmc.2010.04.002] |
51. Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ.. (2009) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum., 5 (10): [PMID:19734910] [10.1038/nchembio.215] |
52. PubChem BioAssay data set, |
53. PubChem BioAssay data set, |
54. PubChem BioAssay data set, |
55. Liu H, Altenbach RJ, Carr TL, Chandran P, Hsieh GC, Lewis LG, Manelli AM, Milicic I, Marsh KC, Miller TR, Strakhova MI, Vortherms TA, Wakefield BD, Wetter JM, Witte DG, Honore P, Esbenshade TA, Brioni JD, Cowart MD.. (2008) cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia., 51 (22): [PMID:18983139] [10.1021/jm8007618] |
56. Brown DG, Maier DL, Sylvester MA, Hoerter TN, Menhaji-Klotz E, Lasota CC, Hirata LT, Wilkins DE, Scott CW, Trivedi S, Chen T, McCarthy DJ, Maciag CM, Sutton EJ, Cumberledge J, Mathisen D, Roberts J, Gupta A, Liu F, Elmore CS, Alhambra C, Krumrine JR, Wang X, Ciaccio PJ, Wood MW, Campbell JB, Johansson MJ, Xia J, Wen X, Jiang J, Wang X, Peng Z, Hu T, Wang J.. (2011) 2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity., 21 (11): [PMID:21524576] [10.1016/j.bmcl.2011.03.117] |
57. Joubert J, van Dyk S, Green IR, Malan SF.. (2011) Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents., 19 (13): [PMID:21665485] [10.1016/j.bmc.2011.05.034] |
58. Joubert J, van Dyk S, Green IR, Malan SF.. (2011) Synthesis, evaluation and application of polycyclic fluorescent analogues as N-methyl-D-aspartate receptor and voltage gated calcium channel ligands., 46 (10): [PMID:21868136] [10.1016/j.ejmech.2011.08.008] |
59. PubChem BioAssay data set, |
60. PubChem BioAssay data set, |
61. Sklyarova AS, Rodionov VN, Parsons CG, Quack G, Schreiner PR, Fokin AA. (2013) Preparation and testing of homocubyl amines as therapeutic NMDA receptor antagonists, 22 (1): [10.1007/s00044-012-0029-7] |
62. Ju C, Song S, Hwang S, Kim C, Kim M, Gu J, Oh YK, Lee K, Kwon J, Lee K, Kim WK, Choi Y.. (2013) Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects., 23 (19): [PMID:23953190] [10.1016/j.bmcl.2013.07.038] |
63. PubChem BioAssay data set, |
64. Banerjee A, Frohlich R, Schepmann D, Wunsch B. (2010) Synthesis and NMDA receptor affinity of dexoxadrol analogues with modifications in position 4 of the piperidine ring, 1 (1): [10.1039/C0MD00017E] |
65. Blokhina SV, Volkova TV, Ol'khovich MV, Sharapova AV, Proshin AN, Bachurin SO, Perlovich GL.. (2014) Synthesis, biological activity, distribution and membrane permeability of novel spiro-thiazines as potent neuroprotectors., 77 [PMID:24607585] [10.1016/j.ejmech.2014.02.052] |
66. Mark Wenlock and Nicholas Tomkinson. Experimental in vitro DMPK and physicochemical data on a set of publicly disclosed compounds, [10.6019/CHEMBL3301361] |
67. Zampieri D, Laurini E, Vio L, Fermeglia M, Pricl S, Wünsch B, Schepmann D, Mamolo MG.. (2015) Improving selectivity preserving affinity: new piperidine-4-carboxamide derivatives as effective sigma-1-ligands., 90 [PMID:25528334] [10.1016/j.ejmech.2014.12.018] |
68. Torres-Gómez H, Lehmkuhl K, Frehland B, Daniliuc C, Schepmann D, Ehrhardt C, Wünsch B.. (2015) Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines., 23 (15): [PMID:26145819] [10.1016/j.bmc.2015.06.030] |
69. Kadernani YE, Zindo FT, Kapp E, Malan SF, Joubert J. (2014) Adamantane amine derivatives as dual acting NMDA receptor and voltage-gated calcium channel inhibitors for neuroprotection, 5 (11): [10.1039/C4MD00244J] |
70. Katzman BM, Perszyk RE, Yuan H, Tahirovic YA, Sotimehin AE, Traynelis SF, Liotta DC.. (2015) A novel class of negative allosteric modulators of NMDA receptor function., 25 (23): [PMID:26525866] [10.1016/j.bmcl.2015.10.046] |
71. Waszkielewicz AM, Gunia-Krzyżak A, Powroźnik B, Słoczyńska K, Pękala E, Walczak M, Bednarski M, Żesławska E, Nitek W, Marona H.. (2016) Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents., 24 (8): [PMID:26988801] [10.1016/j.bmc.2016.03.006] |
72. Galla F, Bourgeois C, Lehmkuhl K, Schepmann D, Soeberdt M, Lotts T, Abels C, Stander S, Wunsch B. (2016) Effects of polar receptor agonists designed for the periphery on ATP-induced Ca2+release from keratinocytes, 7 (2): [10.1039/C5MD00414D] |
73. Xie D, Lu J, Xie J, Cui J, Li TF, Wang YC, Chen Y, Gong N, Li XY, Fu L, Wang YX.. (2016) Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor., 117 [PMID:27089209] [10.1016/j.ejmech.2016.04.017] |
74. Gunia-Krzyżak A, Żelaszczyk D, Rapacz A, Żesławska E, Waszkielewicz AM, Pańczyk K, Słoczyńska K, Pękala E, Nitek W, Filipek B, Marona H.. (2017) Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3., 25 (2): [PMID:27876250] [10.1016/j.bmc.2016.11.014] |
75. Soeberdt M, Molenveld P, Storcken RP, Bouzanne des Mazery R, Sterk GJ, Autar R, Bolster MG, Wagner C, Aerts SN, van Holst FR, Wegert A, Tangherlini G, Frehland B, Schepmann D, Metze D, Lotts T, Knie U, Lin KY, Huang TY, Lai CC, Ständer S, Wünsch B, Abels C.. (2017) Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo., 60 (6): [PMID:28218838] [10.1021/acs.jmedchem.6b01868] |
76. Asare-Nkansah S, Schepmann D, Wünsch B.. (2017) Synthesis of conformationally restricted 1,3-dioxanes to analyze the bioactive conformation of 1,3-dioxane-based σ1 and PCP receptor antagonists., 25 (8): [PMID:28320613] [10.1016/j.bmc.2017.03.014] |
77. Shuto Y, Thum S, Temme L, Schepmann D, Kitamura M, Wünsch B.. (2017) Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?, 8 (5): [PMID:30108812] [10.1039/C6MD00621C] |
78. Thum S, Schepmann D, Ayet E, Pujol M, Nieto FR, Ametamey SM, Wünsch B.. (2019) Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity., 177 [PMID:31129453] [10.1016/j.ejmech.2019.05.034] |
79. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
80. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
81. Ellen Van Damme. (2021) Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activity, [10.6019/CHEMBL4651402] |
82. Morelli MB,Amantini C,Nabissi M,Santoni G,Wünsch B,Schepmann D,Cimarelli C,Pellei M,Santini C,Fontana S,Mammoli V,Quaglia W,Bonifazi A,Giannella M,Giorgioni G,Piergentili A,Del Bello F. (2019) Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells., 10 (4.0): [PMID:30996788] [10.1021/acsmedchemlett.8b00536] |
83. Das J. (2020) Repurposing of Drugs-The Ketamine Story., 63 (22): [PMID:32915563] [10.1021/acs.jmedchem.0c01193] |
84. Alshammari MD,Kucheryavy PV,Ashpole NM,Colby DA. (2021) Synthesis, biological evaluation, and NMR studies of 3-fluorinated derivatives of 3',4',5'-trihydroxyflavone and 3',4',5'-trimethoxyflavone., 32 [PMID:33259925] [10.1016/j.bmcl.2020.127720] |
85. Toublet FX,Lalut J,Hatat B,Lecoutey C,Davis A,Since M,Corvaisier S,Freret T,Sopková-de Oliveira Santos J,Claeysen S,Boulouard M,Dallemagne P,Rochais C. (2021) Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT receptor antagonist with therapeutic interest in Alzheimer's disease., 210 [PMID:33310288] [10.1016/j.ejmech.2020.113059] |
86. Bernhard Ellinger, Justus Dick, Vanessa Lage-Rupprecht, Bruce Schultz, Andrea Zaliani, Marcin Namysl, Stephan Gebel, Ole Pless, Jeanette Reinshagen, Christian Ebeling, Alexander Esser, Marc Jacobs, Carsten Claussen, and Martin Hofmann-Apitius. (2021) HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators, [10.6019/CHEMBL4808148] |
87. Gorecki L, Misiachna A, Damborsky J, Dolezal R, Korabecny J, Cejkova L, Hakenova K, Chvojkova M, Karasova JZ, Prchal L, Novak M, Kolcheva M, Kortus S, Vales K, Horak M, Soukup O.. (2021) Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors., 219 [PMID:33892271] [10.1016/j.ejmech.2021.113434] |
88. (2022) Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte), [10.6019/CHEMBL5058564] |
89. EUbOPEN. (2022) EUbOPEN Chemogenomics Library wave 2 - DSF, [10.6019/CHEMBL5060014] |
90. EUbOPEN. (2023) GPCR results for EUbOPEN Chemogenomics Library 3, [10.6019/CHEMBL5209801] |