ID: ALA286078
Chembl Id: CHEMBL286078
PubChem CID: 14846653
Max Phase: Preclinical
Molecular Formula: C20H41N5O10
Molecular Weight: 511.57
Molecule Type: Small molecule
Associated Items:
Canonical SMILES: CCOCC1OC(OC2C(N)CC(N)C(OC3OC(CN)C(O)C(O)C3N)C2O)C(O)C(N)C1O
Standard InChI: InChI=1S/C20H41N5O10/c1-2-31-5-9-12(26)10(24)15(29)20(33-9)35-18-7(23)3-6(22)17(16(18)30)34-19-11(25)14(28)13(27)8(4-21)32-19/h6-20,26-30H,2-5,21-25H2,1H3
Standard InChI Key: ZWACHAQQMJWCQJ-UHFFFAOYSA-N
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
| Molecule Type: Small molecule | Topical: No | First In Class: No | Black Box: No |
| Chirality: No | Availability: No | Prodrug: No |
| MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Molecular Weight: 511.57 | Molecular Weight (Monoisotopic): 511.2853 | AlogP: -6.28 | #Rotatable Bonds: 8 |
| Polar Surface Area: 277.40 | Molecular Species: BASE | HBA: 15 | HBD: 10 |
| #RO5 Violations: 3 | HBA (Lipinski): 15 | HBD (Lipinski): 15 | #RO5 Violations (Lipinski): 3 |
| CX Acidic pKa: 12.39 | CX Basic pKa: 9.54 | CX LogP: -6.17 | CX LogD: -12.39 |
| Aromatic Rings: ┄ | Heavy Atoms: 35 | QED Weighted: 0.14 | Np Likeness Score: 1.18 |
| 1. Mingeot-Leclercq MP, Van Schepdael A, Brasseur R, Busson R, Vanderhaeghe HJ, Claes PJ, Tulkens PM.. (1991) New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 2. In vitro and computer-aided toxicological evaluation with respect to interactions with phosphatidylinositol., 34 (4): [PMID:2016725] [10.1021/jm00108a036] |
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