(S)-diphenyl2-chloro-1-hydroxy-1-(4-chlorophenyl)ethylphosphonate

ID: ALA3098875

Chembl Id: CHEMBL3098875

PubChem CID: 72948067

Max Phase: Preclinical

Molecular Formula: C20H17Cl2O4P

Molecular Weight: 423.23

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  O=P(Oc1ccccc1)(Oc1ccccc1)[C@](O)(CCl)c1ccc(Cl)cc1

Standard InChI:  InChI=1S/C20H17Cl2O4P/c21-15-20(23,16-11-13-17(22)14-12-16)27(24,25-18-7-3-1-4-8-18)26-19-9-5-2-6-10-19/h1-14,23H,15H2/t20-/m1/s1

Standard InChI Key:  CLOLHBYRBPQONJ-HXUWFJFHSA-N

Associated Targets(non-human)

Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus cereus (7522 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Stenotrophomonas maltophilia (1743 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter haemolyticus (65 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 423.23Molecular Weight (Monoisotopic): 422.0242AlogP: 6.08#Rotatable Bonds: 7
Polar Surface Area: 55.76Molecular Species: NEUTRALHBA: 4HBD: 1
#RO5 Violations: 1HBA (Lipinski): 4HBD (Lipinski): 1#RO5 Violations (Lipinski): 1
CX Acidic pKa: 10.76CX Basic pKa: CX LogP: 6.32CX LogD: 6.32
Aromatic Rings: 3Heavy Atoms: 27QED Weighted: 0.37Np Likeness Score: -0.25

References

1. Faísca Phillips AM, Barros MT, Pacheco M, Dias R..  (2014)  Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents.,  24  (1): [PMID:24360606] [10.1016/j.bmcl.2013.12.002]

Source