3-Nitro-N-(4-carboxy-2-hydroxyphenyl)-1,8-naphthalimide

ID: ALA3110161

Chembl Id: CHEMBL3110161

PubChem CID: 71234741

Max Phase: Preclinical

Molecular Formula: C19H10N2O7

Molecular Weight: 378.30

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  O=C(O)c1ccc(N2C(=O)c3cccc4cc([N+](=O)[O-])cc(c34)C2=O)c(O)c1

Standard InChI:  InChI=1S/C19H10N2O7/c22-15-7-10(19(25)26)4-5-14(15)20-17(23)12-3-1-2-9-6-11(21(27)28)8-13(16(9)12)18(20)24/h1-8,22H,(H,25,26)

Standard InChI Key:  UQKQMDPBIOJNLZ-UHFFFAOYSA-N

Associated Targets(Human)

CLTC Tbio Clathrin heavy chain 1 (36 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 378.30Molecular Weight (Monoisotopic): 378.0488AlogP: 2.95#Rotatable Bonds: 3
Polar Surface Area: 138.05Molecular Species: ACIDHBA: 6HBD: 2
#RO5 Violations: HBA (Lipinski): 9HBD (Lipinski): 2#RO5 Violations (Lipinski):
CX Acidic pKa: 3.82CX Basic pKa: CX LogP: 2.86CX LogD: -0.45
Aromatic Rings: 3Heavy Atoms: 28QED Weighted: 0.41Np Likeness Score: -0.65

References

1. MacGregor KA, Robertson MJ, Young KA, von Kleist L, Stahlschmidt W, Whiting A, Chau N, Robinson PJ, Haucke V, McCluskey A..  (2014)  Development of 1,8-naphthalimides as clathrin inhibitors.,  57  (1): [PMID:24299503] [10.1021/jm4015263]

Source