4-(pyrrolidin-1-yl)-1-(3-(2-(pyrrolidin-1-yl)ethyl)phenyl)piperidine

ID: ALA3134135

Chembl Id: CHEMBL3134135

PubChem CID: 76318508

Max Phase: Preclinical

Molecular Formula: C21H33N3

Molecular Weight: 327.52

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  c1cc(CCN2CCCC2)cc(N2CCC(N3CCCC3)CC2)c1

Standard InChI:  InChI=1S/C21H33N3/c1-2-12-22(11-1)15-8-19-6-5-7-21(18-19)24-16-9-20(10-17-24)23-13-3-4-14-23/h5-7,18,20H,1-4,8-17H2

Standard InChI Key:  XXCKYCGUYJJDNV-UHFFFAOYSA-N

Associated Targets(Human)

L3MBTL3 Tchem Lethal(3)malignant brain tumor-like protein 3 (224 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PHF23 Tbio PHD finger protein 23 (81 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM5A Tchem Lysine-specific demethylase 5A (893 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UHRF1 Tbio E3 ubiquitin-protein ligase UHRF1 (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX7 Tchem Chromobox protein homolog 7 (354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53BP1 Tbio Tumor suppressor p53-binding protein 1 (103 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MBTD1 Tbio MBT domain-containing protein 1 (145 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 327.52Molecular Weight (Monoisotopic): 327.2674AlogP: 3.39#Rotatable Bonds: 5
Polar Surface Area: 9.72Molecular Species: BASEHBA: 3HBD:
#RO5 Violations: HBA (Lipinski): 3HBD (Lipinski): #RO5 Violations (Lipinski):
CX Acidic pKa: CX Basic pKa: 10.22CX LogP: 3.15CX LogD: -1.66
Aromatic Rings: 1Heavy Atoms: 24QED Weighted: 0.82Np Likeness Score: -1.17

References

1. Camerino MA, Zhong N, Dong A, Dickson BM, James LI, Baughman BM, Norris JL, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV..  (2013)  The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.,  (11): [PMID:24466405] [10.1039/c3md00197k]

Source