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N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-acetamide
ID: ALA314596
Chembl Id: CHEMBL314596
Cas Number: 161314-48-3
PubChem CID: 10545870
Max Phase: Preclinical
Molecular Formula: C15H17N3O5S
Molecular Weight: 351.38
Molecule Type: Small molecule
Associated Items:
Names and Identifiers
Canonical SMILES: COc1ccc(S(=O)(=O)N(CC(=O)NO)Cc2cccnc2)cc1
Standard InChI: InChI=1S/C15H17N3O5S/c1-23-13-4-6-14(7-5-13)24(21,22)18(11-15(19)17-20)10-12-3-2-8-16-9-12/h2-9,20H,10-11H2,1H3,(H,17,19)
Standard InChI Key: YYCNZECYSJUTIY-UHFFFAOYSA-N
Associated Targets(Human)
Associated Targets(non-human)
Molecule Features
Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
Molecule Type: Small molecule | Topical: No | First In Class: No | Black Box: No |
Chirality: No | Availability: No | Prodrug: No |
Drug Indications
MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
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Mechanisms of Action
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Calculated Properties
Molecular Weight: 351.38 | Molecular Weight (Monoisotopic): 351.0889 | AlogP: 0.79 | #Rotatable Bonds: 7 |
Polar Surface Area: 108.83 | Molecular Species: NEUTRAL | HBA: 6 | HBD: 2 |
#RO5 Violations: ┄ | HBA (Lipinski): 8 | HBD (Lipinski): 2 | #RO5 Violations (Lipinski): ┄ |
CX Acidic pKa: 8.74 | CX Basic pKa: 4.81 | CX LogP: 0.04 | CX LogD: 0.02 |
Aromatic Rings: 2 | Heavy Atoms: 24 | QED Weighted: 0.56 | Np Likeness Score: -1.67 |
References
1. MacPherson LJ, Bayburt EK, Capparelli MP, Carroll BJ, Goldstein R, Justice MR, Zhu L, Hu S, Melton RA, Fryer L, Goldberg RL, Doughty JR, Spirito S, Blancuzzi V, Wilson D, O'Byrne EM, Ganu V, Parker DT.. (1997) Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits., 40 (16): [PMID:9258358] [10.1021/jm960871c] |
2. Jeng AY, Chou M, Parker DT.. (1998) Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase., 8 (8): [PMID:9871508] [10.1016/s0960-894x(98)00142-5] |