(2S,5S)-1-((4E,6E)-(2S,3S,8S,9S)-3-Acetylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoyl)-pyrrolidine-2,5-dicarboxylic acid

ID: ALA318434

Chembl Id: CHEMBL318434

PubChem CID: 44330395

Max Phase: Preclinical

Molecular Formula: C28H38N2O7

Molecular Weight: 514.62

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  CO[C@@H](Cc1ccccc1)[C@@H](C)/C=C(C)/C=C/[C@H](NC(C)=O)[C@H](C)C(=O)N1[C@H](C(=O)O)CC[C@H]1C(=O)O

Standard InChI:  InChI=1S/C28H38N2O7/c1-17(15-18(2)25(37-5)16-21-9-7-6-8-10-21)11-12-22(29-20(4)31)19(3)26(32)30-23(27(33)34)13-14-24(30)28(35)36/h6-12,15,18-19,22-25H,13-14,16H2,1-5H3,(H,29,31)(H,33,34)(H,35,36)/b12-11+,17-15+/t18-,19-,22-,23-,24-,25-/m0/s1

Standard InChI Key:  MMDIKOPVRPYPJW-FSDTYISRSA-N

Associated Targets(Human)

PPM1B Tchem Protein phosphatase 2C beta (71 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

PPP2CA Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform (49 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 514.62Molecular Weight (Monoisotopic): 514.2679AlogP: 3.05#Rotatable Bonds: 12
Polar Surface Area: 133.24Molecular Species: ACIDHBA: 5HBD: 3
#RO5 Violations: 1HBA (Lipinski): 9HBD (Lipinski): 3#RO5 Violations (Lipinski): 1
CX Acidic pKa: 3.35CX Basic pKa: CX LogP: 2.91CX LogD: -3.69
Aromatic Rings: 1Heavy Atoms: 37QED Weighted: 0.37Np Likeness Score: 0.73

References

1. Gulledge BM, Aggen JB, Eng H, Sweimeh K, Chamberlin AR..  (2003)  Microcystin analogues comprised only of Adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors.,  13  (17): [PMID:14611855] [10.1016/s0960-894x(03)00588-2]

Source