ID: ALA3245229

Max Phase: Preclinical

Molecular Formula: C20H39N5O8

Molecular Weight: 477.56

Molecule Type: Small molecule

Representations

Canonical SMILES:  CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3OC(CNOC)=CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O

Standard InChI:  InChI=1S/C20H39N5O8/c1-20(28)8-30-19(14(27)17(20)24-2)33-16-12(23)6-11(22)15(13(16)26)32-18-10(21)5-4-9(31-18)7-25-29-3/h4,10-19,24-28H,5-8,21-23H2,1-3H3/t10-,11+,12-,13+,14-,15-,16+,17-,18-,19-,20+/m1/s1

Standard InChI Key:  LKPKLGQMNZDGMX-CPIRLDNISA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Properties

Molecular Weight: 477.56

Molecular Weight (Monoisotopic): 477.2799

AlogP: -3.66

#Rotatable Bonds: 8

Polar Surface Area: 208.96

Molecular Species: BASE

HBA: 13

HBD: 8

#RO5 Violations: 2

HBA (Lipinski): 13

HBD (Lipinski): 11

#RO5 Violations (Lipinski): 2

CX Acidic pKa: 12.55

CX Basic pKa: 9.68

CX LogP: -3.83

CX LogD: -9.52

Aromatic Rings: 0

Heavy Atoms: 33

QED Weighted: 0.16

Np Likeness Score: 1.78

References

1. Davies DH, Mallams AK, Counelis M, Loebenberg D, Moss EL, Waitz JA..  (1978)  Semisynthetic aminoglycoside antibacterials. 6. Synthesis of sisomicin, Antibiotic G-52, and novel 6'-substituted analogues of sisomicin from aminoglycoside 66-40C.,  21  (2): [PMID:413921] [10.1021/jm00200a009]

Source

Source(1):

• Scientific Literature