4-(1,3,2-dithiarsinan-2-yl)aniline

ID: ALA3290761

Chembl Id: CHEMBL3290761

Cas Number: 256348-71-7

PubChem CID: 10683647

Max Phase: Preclinical

Molecular Formula: C9H12AsNS2

Molecular Weight: 273.26

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  Nc1ccc([As]2SCCCS2)cc1

Standard InChI:  InChI=1S/C9H12AsNS2/c11-9-4-2-8(3-5-9)10-12-6-1-7-13-10/h2-5H,1,6-7,11H2

Standard InChI Key:  WONBTYJJKXSAKA-UHFFFAOYSA-N

Alternative Forms

1. Parent:

   

   ALA3290761

   Pao-pdt

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 273.26

Molecular Weight (Monoisotopic): 272.9627

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References

1. Liu Y, Duan D, Yao J, Zhang B, Peng S, Ma H, Song Y, Fang J..  (2014)  Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.,  57  (12): [PMID:24867309] [10.1021/jm500221p]

2. Fan XY, Liu YJ, Cai YM, Wang AD, Xia YZ, Hu YJ, Jiang FL, Liu Y..  (2019)  A mitochondria-targeted organic arsenical accelerates mitochondrial metabolic disorder and function injury.,  27  (5): [PMID:30665675] [10.1016/j.bmc.2019.01.008]

3. Song ZL, Zhang J, Xu Q, Shi D, Yao X, Fang J..  (2021)  Structural Modification of Aminophenylarsenoxides Generates Candidates for Leukemia Treatment via Thioredoxin Reductase Inhibition.,  64  (21.0): [PMID:34704769] [10.1021/acs.jmedchem.1c01441]

Source

Source(1):

• Scientific Literature