1. Goff DA, Koolpe GA, Kelson AB, Vu HM, Taylor DL, Bedford CD, Musallam HA, Koplovitz I, Harris RN.. (1991) Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication., 34 (4): [PMID:2016711] [10.1021/jm00108a019] |
2. Koolpe GA, Lovejoy SM, Goff DA, Lin KY, Leung DS, Bedford CD, Musallam HA, Koplovitz I, Harris RN.. (1991) Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 5. Structure-activity relationships for side-chain nitro-, sulfone-, amino-, and aminosulfonyl-substituted analogues for therapy against anticholinesterase intoxication., 34 (4): [PMID:2016712] [10.1021/jm00108a020] |
3. Bedford CD, Harris RN, Howd RA, Miller A, Nolen HW, Kenley RA.. (1984) Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole., 27 (11): [PMID:6492073] [10.1021/jm00377a010] |
4. Bedford CD, Miura M, Bottaro JC, Howd RA, Nolen HW.. (1986) Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro., 29 (9): [PMID:3746817] [10.1021/jm00159a021] |
5. Kuca K, Bielavský J, Cabal J, Kassa J.. (2003) Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase., 13 (20): [PMID:14505667] [10.1016/s0960-894x(03)00751-0] |
6. Bedford CD, Harris RN, Howd RA, Goff DA, Koolpe GA, Petesch M, Miller A, Nolen HW, Musallam HA, Pick RO.. (1989) Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases., 32 (2): [PMID:2913310] [10.1021/jm00122a034] |
7. Bedford CD, Harris RN, Howd RA, Goff DA, Koolpe GA, Petesch M, Koplovitz I, Sultan WE, Musallam HA.. (1989) Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 3. Synthesis and evaluation of (alkenyloxy)-, (alkynyloxy)-, and (aralkyloxy)methyl quaternarized 2-[(hydroxyimino)methyl]-1-alkylimidazolium halides as reactivators and therapy for soman intoxication., 32 (2): [PMID:2913311] [10.1021/jm00122a035] |
8. Musilek K, Kuca K, Jun D, Dohnal V, Dolezal M, Dolezal M.. (2006) Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase., 16 (3): [PMID:16288867] [10.1016/j.bmcl.2005.10.059] |
9. Oh KA, Yang GY, Jun D, Kuca K, Jung YS.. (2006) Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX., 16 (18): [PMID:16828550] [10.1016/j.bmcl.2006.06.063] |
10. Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M, Dolezal M.. (2006) Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase., 16 (21): [PMID:16934462] [10.1016/j.bmcl.2006.08.011] |
11. Musilek K, Holas O, Jun D, Dohnal V, Gunn-Moore F, Opletalova V, Dolezal M, Dolezal M, Kuca K.. (2007) Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase., 15 (21): [PMID:17764957] [10.1016/j.bmc.2007.08.002] |
12. Yang GY, Oh KA, Park NJ, Jung YS.. (2007) New oxime reactivators connected with CH2O(CH2)nOCH2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase., 15 (24): [PMID:17869525] [10.1016/j.bmc.2007.08.056] |
13. Musilek K, Jun D, Cabal J, Kassa J, Gunn-Moore F, Kuca K.. (2007) Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203)., 50 (22): [PMID:17924614] [10.1021/jm070653r] |
14. Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M, Dolezal M.. (2007) Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase., 17 (11): [PMID:17383875] [10.1016/j.bmcl.2007.03.025] |
15. Musilek K, Kucera J, Jun D, Dohnal V, Opletalova V, Kuca K.. (2008) Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase., 16 (17): [PMID:18676153] [10.1016/j.bmc.2008.07.036] |
16. Butini S, Campiani G, Borriello M, Gemma S, Panico A, Persico M, Catalanotti B, Ros S, Brindisi M, Agnusdei M, Fiorini I, Nacci V, Novellino E, Belinskaya T, Saxena A, Fattorusso C.. (2008) Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors., 51 (11): [PMID:18479118] [10.1021/jm701253t] |
17. Jeong HC, Kang NS, Park NJ, Yum EK, Jung YS.. (2009) Reactivation potency of fluorinated pyridinium oximes for acetylcholinesterases inhibited by paraoxon organophosphorus agent., 19 (4): [PMID:19124241] [10.1016/j.bmcl.2008.12.070] |
18. Jeong HC, Park NJ, Chae CH, Musilek K, Kassa J, Kuca K, Jung YS.. (2009) Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent., 17 (17): [PMID:19665386] [10.1016/j.bmc.2009.07.043] |
19. Musilek K, Komloova M, Holas O, Horova A, Pohanka M, Gunn-Moore F, Dohnal V, Dolezal M, Dolezal M, Kuca K.. (2011) Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking., 19 (2): [PMID:21215642] [10.1016/j.bmc.2010.12.021] |
20. Kalisiak J, Ralph EC, Zhang J, Cashman JR.. (2011) Amidine-oximes: reactivators for organophosphate exposure., 54 (9): [PMID:21438612] [10.1021/jm200054r] |
21. Mercey G, Renou J, Verdelet T, Kliachyna M, Baati R, Gillon E, Arboléas M, Loiodice M, Nachon F, Jean L, Renard PY.. (2012) Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase., 55 (23): [PMID:23148598] [10.1021/jm3015519] |
22. Andersson CD, Forsgren N, Akfur C, Allgardsson A, Berg L, Engdahl C, Qian W, Ekström F, Linusson A.. (2013) Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors., 56 (19): [PMID:23984975] [10.1021/jm400990p] |
23. Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radić Z.. (2014) Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification., 57 (4): [PMID:24571195] [10.1021/jm401650z] |
24. Karade HN, Valiveti AK, Acharya J, Kaushik MP.. (2014) Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE)., 22 (9): [PMID:24721830] [10.1016/j.bmc.2014.03.023] |
25. Santoni G, de Sousa J, de la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F.. (2018) Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents., 61 (17): [PMID:30125110] [10.1021/acs.jmedchem.8b00592] |
26. Zorbaz T, Malinak D, Maraković N, Maček Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinić M, Kuca K, Kovarik Z, Musilek K.. (2018) Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents., 61 (23): [PMID:30383374] [10.1021/acs.jmedchem.8b01398] |
27. Kim J, Malpani YR, Lee J, Shin JS, Han SB, Jung YS.. (2018) Novel tacrine-pyridinium hybrid reactivators of organophosphorus-inhibited acetylcholinesterase: Synthesis, molecular docking, and in vitro reactivation study., 28 (23-24): [PMID:30301674] [10.1016/j.bmcl.2018.10.006] |
28. Da Silva O, Probst N, Landry C, Hanak AS, Warnault P, Coisne C, Calas AG, Gosselet F, Courageux C, Gastellier AJ, Trancart M, Baati R, Dehouck MP, Jean L, Nachon F, Renard PY, Dias J.. (2022) A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning., 65 (6.0): [PMID:35255209] [10.1021/acs.jmedchem.1c01748] |
29. Zorbaz T, Malinak D, Hofmanova T, Maraković N, Žunec S, Hrvat NM, Andrys R, Psotka M, Zandona A, Svobodova J, Prchal L, Fingler S, Katalinić M, Kovarik Z, Musilek K.. (2022) Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents., 238 [PMID:35526478] [10.1016/j.ejmech.2022.114377] |