| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ID: ALA330526
Max Phase: Preclinical
Molecular Formula: C21H19BrFN3O4
Molecular Weight: 476.30
Molecule Type: Small molecule
Associated Items:
Representations
Canonical SMILES: O=C(N/C(C(=O)N1CCCCC1)=C(/Br)c1ccccc1F)c1ccc([N+](=O)[O-])cc1
Standard InChI: InChI=1S/C21H19BrFN3O4/c22-18(16-6-2-3-7-17(16)23)19(21(28)25-12-4-1-5-13-25)24-20(27)14-8-10-15(11-9-14)26(29)30/h2-3,6-11H,1,4-5,12-13H2,(H,24,27)/b19-18+
Standard InChI Key: HSNWFDKBQQJTQE-VHEBQXMUSA-N
Associated Targets(non-human)
Human immunodeficiency virus 1 (70413 Activities)
Human alphaherpesvirus 1 (11089 Activities)
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Newcastle disease virus (78 Activities)
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Vesicular stomatitis virus (4460 Activities)
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Marmota monax (83 Activities)
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Anas sp. (58 Activities)
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Molecule Features
| Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
| Molecule Type: Small molecule | Topical: No | First In Class: No | Black Box: No |
| Chirality: No | Availability: No | Prodrug: No |
Drug Indications
| MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Properties
| Molecular Weight: 476.30 | Molecular Weight (Monoisotopic): 475.0543 | AlogP: 4.24 | #Rotatable Bonds: 5 |
| Polar Surface Area: 92.55 | Molecular Species: NEUTRAL | HBA: 4 | HBD: 1 |
| #RO5 Violations: 0 | HBA (Lipinski): 7 | HBD (Lipinski): 1 | #RO5 Violations (Lipinski): 0 |
| CX Acidic pKa: 10.42 | CX Basic pKa: | CX LogP: 3.55 | CX LogD: 3.55 |
| Aromatic Rings: 2 | Heavy Atoms: 30 | QED Weighted: 0.40 | Np Likeness Score: -1.50 |
References
| 1. Perni RB, Conway SC, Ladner SK, Zaifert K, Otto MJ, King RW.. (2000) Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication., 10 (23): [PMID:11128652] [10.1016/s0960-894x(00)00544-8] |
Source
Source(1):