ID: ALA3322505

Max Phase: Preclinical

Molecular Formula: C19H18N2O6S

Molecular Weight: 402.43

Molecule Type: Small molecule

Representations

Canonical SMILES:  O=C1C(=O)N(CCCCNS(=O)(=O)c2ccccc2C(=O)O)c2ccccc21

Standard InChI:  InChI=1S/C19H18N2O6S/c22-17-13-7-1-3-9-15(13)21(18(17)23)12-6-5-11-20-28(26,27)16-10-4-2-8-14(16)19(24)25/h1-4,7-10,20H,5-6,11-12H2,(H,24,25)

Standard InChI Key:  AAIOGEOORVSWNA-UHFFFAOYSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Properties

Molecular Weight: 402.43

Molecular Weight (Monoisotopic): 402.0886

AlogP: 1.67

#Rotatable Bonds: 8

Polar Surface Area: 120.85

Molecular Species: ACID

HBA: 5

HBD: 2

#RO5 Violations: 0

HBA (Lipinski): 8

HBD (Lipinski): 2

#RO5 Violations (Lipinski): 0

CX Acidic pKa: 2.17

CX Basic pKa:

CX LogP: 1.68

CX LogD: -1.84

Aromatic Rings: 2

Heavy Atoms: 28

QED Weighted: 0.51

Np Likeness Score: -1.13

References

1. Patil R, Fells JI, Szabó E, Lim KG, Norman DD, Balogh A, Patil S, Strobos J, Miller DD, Tigyi GJ..  (2014)  Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.,  57  (16): [PMID:25100502] [10.1021/jm5007116]

Source

Source(1):

• Scientific Literature