(5-chloropyrimidin-2-yl)(4-(5-fluoro-6-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)pyrimidin-4-yloxy)piperidin-1-yl)methanone

ID: ALA3326689

Chembl Id: CHEMBL3326689

PubChem CID: 118711798

Max Phase: Preclinical

Molecular Formula: C21H20ClFN6O5S

Molecular Weight: 522.95

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  Cc1nc(S(C)(=O)=O)ccc1Oc1ncnc(OC2CCN(C(=O)c3ncc(Cl)cn3)CC2)c1F

Standard InChI:  InChI=1S/C21H20ClFN6O5S/c1-12-15(3-4-16(28-12)35(2,31)32)34-20-17(23)19(26-11-27-20)33-14-5-7-29(8-6-14)21(30)18-24-9-13(22)10-25-18/h3-4,9-11,14H,5-8H2,1-2H3

Standard InChI Key:  BPXJSGIERMPYKH-UHFFFAOYSA-N

Alternative Forms

1. Parent:

   

   ALA3326689

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Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 522.95

Molecular Weight (Monoisotopic): 522.0888

AlogP: 2.64

#Rotatable Bonds: 6

Polar Surface Area: 137.36

Molecular Species: NEUTRAL

HBA: 10

HBD: ┄

#RO5 Violations: 1

HBA (Lipinski): 11

HBD (Lipinski): ┄

#RO5 Violations (Lipinski): 2

CX Acidic pKa: ┄

CX Basic pKa: 0.66

CX LogP: 1.48

CX LogD: 1.48

Aromatic Rings: 3

Heavy Atoms: 35

QED Weighted: 0.47

Np Likeness Score: -1.25

References

1. Buzard DJ, Kim SH, Lehmann J, Han S, Calderon I, Wong A, Kawasaki A, Narayanan S, Bhat R, Gharbaoui T, Lopez L, Yue D, Whelan K, Al-Shamma H, Unett DJ, Shu HH, Tung SF, Chang S, Chuang CF, Morgan M, Sadeque A, Chu ZL, Leonard JN, Jones RM..  (2014)  Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists.,  24  (17): [PMID:25088191] [10.1016/j.bmcl.2014.06.071]

Source

Source(1):

• Scientific Literature