ID: ALA3337861

Max Phase: Preclinical

Molecular Formula: C38H44N4O

Molecular Weight: 572.80

Molecule Type: Small molecule

Representations

Canonical SMILES:  CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO

Standard InChI:  InChI=1S/C38H44N4O/c1-2-23-19-39-14-12-37-29-7-3-6-10-32(29)42-22-28-26-18-34-38(13-15-40(34)20-24(26)11-16-43)30-8-4-5-9-31(30)41(36(28)38)21-27(35(37)42)25(23)17-33(37)39/h3-10,21-26,33-36,43H,2,11-20H2,1H3/b27-21-,28-22-/t23-,24-,25+,26+,33+,34+,35+,36+,37-,38-/m1/s1

Standard InChI Key:  QAVRQLXVMMTXOP-NILLWRJDSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Properties

Molecular Weight: 572.80

Molecular Weight (Monoisotopic): 572.3515

AlogP: 5.26

#Rotatable Bonds: 3

Polar Surface Area: 33.19

Molecular Species: BASE

HBA: 5

HBD: 1

#RO5 Violations: 2

HBA (Lipinski): 5

HBD (Lipinski): 1

#RO5 Violations (Lipinski): 2

CX Acidic pKa:

CX Basic pKa: 10.90

CX LogP: 4.37

CX LogD: -1.60

Aromatic Rings: 2

Heavy Atoms: 43

QED Weighted: 0.54

Np Likeness Score: 1.20

References

1. Zlotos DP, Tränkle C, Holzgrabe U, Gündisch D, Jensen AA..  (2014)  Semisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.,  77  (9): [PMID:25192059] [10.1021/np500259j]

Source

Source(1):

• Scientific Literature