| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ID: ALA3356090
Max Phase: Preclinical
Molecular Formula: C28H23N4O7PS
Molecular Weight: 590.55
Molecule Type: Small molecule
Associated Items:
Representations
Canonical SMILES: O=P(O)(O)OC[C@H]1O[C@@H](n2cnc3c(-c4cccc(-c5cccc6c5sc5ccccc56)c4)ncnc32)[C@H](O)[C@@H]1O
Standard InChI: InChI=1S/C28H23N4O7PS/c33-24-20(12-38-40(35,36)37)39-28(25(24)34)32-14-31-23-22(29-13-30-27(23)32)16-6-3-5-15(11-16)17-8-4-9-19-18-7-1-2-10-21(18)41-26(17)19/h1-11,13-14,20,24-25,28,33-34H,12H2,(H2,35,36,37)/t20-,24-,25-,28-/m1/s1
Standard InChI Key: PIRFJRGEOQQQOU-QZHHGCDDSA-N
Associated Targets(Human)
DNPH1 Tchem 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (25 Activities)
MCF7 (126967 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Associated Targets(non-human)
Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (25 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Molecule Features
| Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
| Molecule Type: Small molecule | Topical: No | First In Class: No | Black Box: No |
| Chirality: No | Availability: No | Prodrug: No |
Drug Indications
| MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Properties
| Molecular Weight: 590.55 | Molecular Weight (Monoisotopic): 590.1025 | AlogP: 4.26 | #Rotatable Bonds: 6 |
| Polar Surface Area: 160.05 | Molecular Species: ACID | HBA: 10 | HBD: 4 |
| #RO5 Violations: 1 | HBA (Lipinski): 11 | HBD (Lipinski): 4 | #RO5 Violations (Lipinski): 2 |
| CX Acidic pKa: 1.15 | CX Basic pKa: 2.03 | CX LogP: 2.57 | CX LogD: 0.14 |
| Aromatic Rings: 6 | Heavy Atoms: 41 | QED Weighted: 0.21 | Np Likeness Score: 0.24 |
References
| 1. Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S.. (2014) 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities., 85 [PMID:25108359] [10.1016/j.ejmech.2014.07.110] |
Source
Source(1):