5-(Biphenyl-4-ylsulfonamido)-2-hydroxybenzoic Acid

Names and Identifiers

Canonical SMILES: O=C(O)c1cc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)ccc1O

Standard InChI: InChI=1S/C19H15NO5S/c21-18-11-8-15(12-17(18)19(22)23)20-26(24,25)16-9-6-14(7-10-16)13-4-2-1-3-5-13/h1-12,20-21H,(H,22,23)

Standard InChI Key: ZHUKUTFVXZFATC-UHFFFAOYSA-N

Molfile:

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M  END

Alternative Forms

Parent:

ALA3360262
---

Associated Targets(Human)

UQCRB Tbio Cytochrome b-c1 complex subunit 7 (31 Activities)

Discover Target: UQCRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Molecule Features

Natural Product: No	Oral: No	Chemical Probe: No	Parenteral: No
Molecule Type: Small molecule	Topical: No	First In Class: No	Black Box: No
Chirality: No	Availability: No	Prodrug: No

Drug Indications

MESH ID	MESH Heading	EFO IDs	EFO Terms	Max Phase for Indication	References

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Calculated Properties

Molecular Weight: 369.40	Molecular Weight (Monoisotopic): 369.0671	AlogP: 3.56	#Rotatable Bonds: 5
Polar Surface Area: 103.70	Molecular Species: ACID	HBA: 4	HBD: 3
#RO5 Violations: ┄	HBA (Lipinski): 6	HBD (Lipinski): 3	#RO5 Violations (Lipinski): ┄
CX Acidic pKa: 2.66	CX Basic pKa: ┄	CX LogP: 4.11	CX LogD: 0.54
Aromatic Rings: 3	Heavy Atoms: 26	QED Weighted: 0.60	Np Likeness Score: -0.94

References

1. Jung HJ, Cho M, Kim Y, Han G, Kwon HJ.. (2014) Development of a novel class of mitochondrial ubiquinol-cytochrome c reductase binding protein (UQCRB) modulators as promising antiangiogenic leads., 57 (19): [PMID:25244355] [10.1021/jm500863j]

Source

Source(1):

Scientific Literature