5-{2-[3,5-Diisopropyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-cyclopent-1-enyl}-3-methyl-penta-2,4-dienoic acid

ID: ALA337719

Chembl Id: CHEMBL337719

PubChem CID: 10026035

Max Phase: Preclinical

Molecular Formula: C25H31F3O3

Molecular Weight: 436.51

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  CC(/C=C/C1=C(c2cc(C(C)C)cc(C(C)C)c2OCC(F)(F)F)CCC1)=C\C(=O)O

Standard InChI:  InChI=1S/C25H31F3O3/c1-15(2)19-12-21(16(3)4)24(31-14-25(26,27)28)22(13-19)20-8-6-7-18(20)10-9-17(5)11-23(29)30/h9-13,15-16H,6-8,14H2,1-5H3,(H,29,30)/b10-9+,17-11+

Standard InChI Key:  RVXMOCIUWSHBTG-BSDMPFPKSA-N

Alternative Forms

1. Parent:

   

   ALA337719

   5-{2-[3,5-Diisopropyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-cyclopent-1-enyl}-3-methyl-penta-2,4-dienoic acid

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 436.51

Molecular Weight (Monoisotopic): 436.2225

AlogP: 7.40

#Rotatable Bonds: 8

Polar Surface Area: 46.53

Molecular Species: ACID

HBA: 2

HBD: 1

#RO5 Violations: 1

HBA (Lipinski): 3

HBD (Lipinski): 1

#RO5 Violations (Lipinski): 1

CX Acidic pKa: 4.19

CX Basic pKa: ┄

CX LogP: 7.24

CX LogD: 4.20

Aromatic Rings: 1

Heavy Atoms: 31

QED Weighted: 0.34

Np Likeness Score: 0.38

References

1. Michellys PY, Ardecky RJ, Chen JH, D'Arrigo J, Grese TA, Karanewsky DS, Leibowitz MD, Liu S, Mais DA, Mapes CM, Montrose-Rafizadeh C, Ogilvie KM, Reifel-Miller A, Rungta D, Thompson AW, Tyhonas JS, Boehm MF..  (2003)  Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.,  46  (19): [PMID:12954061] [10.1021/jm020401k]

Source

Source(1):

• Scientific Literature