(4aS,4bR,5S,6aS,6bR,8R,9aR)-4b-Fluoro-5-hydroxy-4a,6a-dimethyl-6b-methylsulfanyl-8-propyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-2-one

ID: ALA344763

Chembl Id: CHEMBL344763

PubChem CID: 44363418

Max Phase: Preclinical

Molecular Formula: C24H35FO4S

Molecular Weight: 438.61

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  CCC[C@@H]1O[C@@H]2CC3C4CCC5=CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(SC)O1

Standard InChI:  InChI=1S/C24H35FO4S/c1-5-6-20-28-19-12-17-16-8-7-14-11-15(26)9-10-21(14,2)23(16,25)18(27)13-22(17,3)24(19,29-20)30-4/h11,16-20,27H,5-10,12-13H2,1-4H3/t16?,17?,18-,19+,20+,21-,22-,23-,24-/m0/s1

Standard InChI Key:  AUWLUCGWNSMPSW-MWTISXFVSA-N

Alternative Forms

1. Parent:

   

   ALA344763

   (4R,6R,8R,9S,11S,12R,13S)-12-fluoro-11-hydroxy-9,13-dimethyl-8-methylsulfanyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 438.61

Molecular Weight (Monoisotopic): 438.2240

AlogP: 4.79

#Rotatable Bonds: 3

Polar Surface Area: 55.76

Molecular Species: NEUTRAL

HBA: 5

HBD: 1

#RO5 Violations: ┄

HBA (Lipinski): 4

HBD (Lipinski): 1

#RO5 Violations (Lipinski): ┄

CX Acidic pKa: 13.65

CX Basic pKa: ┄

CX LogP: 4.80

CX LogD: 4.80

Aromatic Rings: ┄

Heavy Atoms: 30

QED Weighted: 0.69

Np Likeness Score: 1.92

References

1. Ashton MJ, Lawrence C, Karlsson JA, Stuttle KA, Newton CG, Vacher BY, Webber S, Withnall MJ..  (1996)  Anti-inflammatory 17beta-thioalkyl-16alpha,17alpha-ketal and -acetal androstanes: a new class of airway selective steroids for the treatment of asthma.,  39  (25): [PMID:8960547] [10.1021/jm9604639]

Source

Source(1):

• Scientific Literature