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(S)-3-(1H-Indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]-N-[[1-(2-pyridinyl)cyclohexyl]methyl]propanamide ID: ALA3590073
Chembl Id: CHEMBL3590073
PubChem CID: 122181322
Max Phase: Preclinical
Molecular Formula: C31H35N5O3
Molecular Weight: 525.65
Molecule Type: Small molecule
Associated Items:
Names and Identifiers Canonical SMILES: COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1
Standard InChI: InChI=1S/C31H35N5O3/c1-39-24-14-12-23(13-15-24)35-30(38)36-27(19-22-20-33-26-10-4-3-9-25(22)26)29(37)34-21-31(16-6-2-7-17-31)28-11-5-8-18-32-28/h3-5,8-15,18,20,27,33H,2,6-7,16-17,19,21H2,1H3,(H,34,37)(H2,35,36,38)/t27-/m0/s1
Standard InChI Key: NTFUQLNNSFGESC-MHZLTWQESA-N
Associated Targets(Human) Associated Targets(non-human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 525.65Molecular Weight (Monoisotopic): 525.2740AlogP: 5.32#Rotatable Bonds: 9Polar Surface Area: 108.14Molecular Species: NEUTRALHBA: 4HBD: 4#RO5 Violations: 2HBA (Lipinski): 8HBD (Lipinski): 4#RO5 Violations (Lipinski): 2CX Acidic pKa: ┄CX Basic pKa: 4.35CX LogP: 4.96CX LogD: 4.96Aromatic Rings: 4Heavy Atoms: 39QED Weighted: 0.24Np Likeness Score: -0.83
References 1. Lacivita E, Schepetkin IA, Stama ML, Kirpotina LN, Colabufo NA, Perrone R, Khlebnikov AI, Quinn MT, Leopoldo M.. (2015) Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2., 23 (14): [PMID:25549897 ] [10.1016/j.bmc.2014.12.007 ]