(R)-N-[[1-(4-Fluorophenyl)cyclohexyl]methyl]-3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamide

ID: ALA3590076

Chembl Id: CHEMBL3590076

PubChem CID: 122181325

Max Phase: Preclinical

Molecular Formula: C32H35FN4O3

Molecular Weight: 542.66

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1

Standard InChI:  InChI=1S/C32H35FN4O3/c1-40-26-15-13-25(14-16-26)36-31(39)37-29(19-22-20-34-28-8-4-3-7-27(22)28)30(38)35-21-32(17-5-2-6-18-32)23-9-11-24(33)12-10-23/h3-4,7-16,20,29,34H,2,5-6,17-19,21H2,1H3,(H,35,38)(H2,36,37,39)/t29-/m1/s1

Standard InChI Key:  BSKZOVBCAGHHCL-GDLZYMKVSA-N

Alternative Forms

  1. Parent:

    ALA3590076

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Associated Targets(Human)

FPR2 Tchem Lipoxin A4 receptor (3472 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FPR1 Tchem Formyl peptide receptor 1 (1372 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Fpr-s1 Formyl peptide receptor-related sequence 1 (29 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 542.66Molecular Weight (Monoisotopic): 542.2693AlogP: 6.07#Rotatable Bonds: 9
Polar Surface Area: 95.25Molecular Species: NEUTRALHBA: 3HBD: 4
#RO5 Violations: 2HBA (Lipinski): 7HBD (Lipinski): 4#RO5 Violations (Lipinski): 2
CX Acidic pKa: CX Basic pKa: CX LogP: 5.93CX LogD: 5.93
Aromatic Rings: 4Heavy Atoms: 40QED Weighted: 0.21Np Likeness Score: -0.88

References

1. Lacivita E, Schepetkin IA, Stama ML, Kirpotina LN, Colabufo NA, Perrone R, Khlebnikov AI, Quinn MT, Leopoldo M..  (2015)  Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2.,  23  (14): [PMID:25549897] [10.1016/j.bmc.2014.12.007]

Source