6-(2,4-Difluorophenyl)-3-(3,4-dimethoxyphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

ID: ALA3596959

PubChem CID: 71812093

Max Phase: Preclinical

Molecular Formula: C22H15F2NO5

Molecular Weight: 411.36

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  COc1ccc(-n2c(=O)oc3ccc(-c4ccc(F)cc4F)cc3c2=O)cc1OC

Standard InChI:  InChI=1S/C22H15F2NO5/c1-28-19-8-5-14(11-20(19)29-2)25-21(26)16-9-12(3-7-18(16)30-22(25)27)15-6-4-13(23)10-17(15)24/h3-11H,1-2H3

Standard InChI Key:  LBUVMNXRCZTZQN-UHFFFAOYSA-N

Molfile:  

     RDKit          2D

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   -5.2125    0.7617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2964   -1.4973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2206   -0.4383    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5317    3.6272    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1925    3.7616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.7486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5929    0.7486    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2964    1.4973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6321   -1.3486    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9086    1.5029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8985    3.0029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2964    1.4973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2964   -1.4973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5065    1.5203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6111   -0.7486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2964    2.6973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8926    1.4990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8951    2.9990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1953    3.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4931    2.9949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4907    1.4949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1905    0.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1946    5.2478    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1555    5.8480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7956    3.7405    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8331    3.1374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  6 15  1  0
  7 13  1  0
 11  2  1  0
  3 13  1  0
 11 15  2  0
  9 20  2  0
  2  4  1  0
  9  7  1  0
 14  8  1  0
 12  5  1  0
  1 11  1  0
 18 12  1  0
  8  9  1  0
 12  6  2  0
 17 19  1  0
  7 16  2  0
  2 18  2  0
 13 17  2  0
  1 16  1  0
  3 14  1  0
 19  1  2  0
 14 10  2  0
 21 22  2  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 21  1  0
  8 21  1  0
 27 28  1  0
 23 27  1  0
 29 30  1  0
 24 29  1  0
M  END

Alternative Forms

1. Parent:

   

   ALA3596959

   6-(2,4-difluorophenyl)-3-(3,4-dimethoxyphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 411.36

Molecular Weight (Monoisotopic): 411.0918

AlogP: 3.91

#Rotatable Bonds: 4

Polar Surface Area: 70.67

Molecular Species: NEUTRAL

HBA: 6

HBD: ┄

#RO5 Violations: ┄

HBA (Lipinski): 6

HBD (Lipinski): ┄

#RO5 Violations (Lipinski): ┄

CX Acidic pKa: ┄

CX Basic pKa: ┄

CX LogP: 4.43

CX LogD: 4.43

Aromatic Rings: 4

Heavy Atoms: 30

QED Weighted: 0.51

Np Likeness Score: -0.88

References

1. Lee CC, Liu FL, Chen CL, Chen TC, Liu FC, Ahmed Ali AA, Chang DM, Huang HS..  (2015)  Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones.,  23  (15): [PMID:26081760] [10.1016/j.bmc.2015.06.007]

Source

Source(1):

• Scientific Literature