Standard InChI: InChI=1S/C62H78N12O6/c1-39(63-3)59(77)67-49-37-71(35-33-43-29-31-51(73(43)61(49)79)57-65-47-25-17-23-45(55(47)69-57)41-19-11-9-12-20-41)53(75)27-15-7-5-6-8-16-28-54(76)72-36-34-44-30-32-52(74(44)62(80)50(38-72)68-60(78)40(2)64-4)58-66-48-26-18-24-46(56(48)70-58)42-21-13-10-14-22-42/h9-14,17-26,39-40,43-44,49-52,63-64H,5-8,15-16,27-38H2,1-4H3,(H,65,69)(H,66,70)(H,67,77)(H,68,78)/t39-,40-,43+,44+,49-,50-,51-,52-/m0/s1
1. (2014) Bivalent diazo bicyclic Smac mimetics and the uses thereof,
2.Sato, Shinichi S, Aoyama, Hiroshi H, Miyachi, Hiroyuki H, Naito, Mikihiko M and Hashimoto, Yuichi Y. 2008-06-01 Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs. [PMID:18448338]
3.Zhang, Bin and 8 more authors. 2008-12-11 Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases. [PMID:19012392]
4.Sun, Wei and 9 more authors. 2009-02-12 Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. [PMID:19138149]
5.Sun, Haiying and 6 more authors. 2010-05-15 Cyclopeptide Smac mimetics as antagonists of IAP proteins. [PMID:20443226]
6.Cai, Qian and 17 more authors. 2011-04-28 A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. [PMID:21443232]
7.Sun, Haiying and 11 more authors. 2011-05-12 Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. [PMID:21462933]
8.Flygare, John A JA and 41 more authors. 2012-05-10 Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). [PMID:22413863]
9.Sheng, Rong R and 13 more authors. 2013-05-23 A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. [PMID:23651223]
10.Zhang, Yong Y and 20 more authors. 2015-07-09 Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer. [PMID:26191364]
11.Baggio, Carlo C and 8 more authors. 2018-07-26 Design of Potent pan-IAP and Lys-Covalent XIAP Selective Inhibitors Using a Thermodynamics Driven Approach. [PMID:29940121]