Standard InChI: InChI=1S/C64H82N12O6/c1-41(65-3)61(79)69-51-39-73(37-35-45-31-33-53(75(45)63(51)81)59-67-49-27-19-25-47(57(49)71-59)43-21-13-11-14-22-43)55(77)29-17-9-7-5-6-8-10-18-30-56(78)74-38-36-46-32-34-54(76(46)64(82)52(40-74)70-62(80)42(2)66-4)60-68-50-28-20-26-48(58(50)72-60)44-23-15-12-16-24-44/h11-16,19-28,41-42,45-46,51-54,65-66H,5-10,17-18,29-40H2,1-4H3,(H,67,71)(H,68,72)(H,69,79)(H,70,80)/t41-,42-,45+,46+,51-,52-,53-,54-/m0/s1
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5.Sun, Haiying and 6 more authors. 2010-05-15 Cyclopeptide Smac mimetics as antagonists of IAP proteins. [PMID:20443226]
6.Cai, Qian and 17 more authors. 2011-04-28 A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. [PMID:21443232]
7.Sun, Haiying and 11 more authors. 2011-05-12 Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. [PMID:21462933]
8.Flygare, John A JA and 41 more authors. 2012-05-10 Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). [PMID:22413863]
9.Sheng, Rong R and 13 more authors. 2013-05-23 A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. [PMID:23651223]
10.Zhang, Yong Y and 20 more authors. 2015-07-09 Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer. [PMID:26191364]
11.Baggio, Carlo C and 8 more authors. 2018-07-26 Design of Potent pan-IAP and Lys-Covalent XIAP Selective Inhibitors Using a Thermodynamics Driven Approach. [PMID:29940121]