The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
US9045389, 10 ID: ALA3673118
Chembl Id: CHEMBL3673118
PubChem CID: 71060017
Max Phase: Preclinical
Molecular Formula: C29H23Cl2FN2O3
Molecular Weight: 537.42
Molecule Type: Small molecule
Associated Items:
Names and Identifiers Canonical SMILES: O=C(O)CCNC(=O)c1ccc(-c2cc(Cl)ccc2CNc2ccc(-c3ccc(Cl)cc3)cc2)cc1F
Standard InChI: InChI=1S/C29H23Cl2FN2O3/c30-22-7-1-18(2-8-22)19-4-10-24(11-5-19)34-17-21-3-9-23(31)16-26(21)20-6-12-25(27(32)15-20)29(37)33-14-13-28(35)36/h1-12,15-16,34H,13-14,17H2,(H,33,37)(H,35,36)
Standard InChI Key: BWNXZCIFSFOSFO-UHFFFAOYSA-N
Associated Targets(Human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 537.42Molecular Weight (Monoisotopic): 536.1070AlogP: 7.28#Rotatable Bonds: 9Polar Surface Area: 78.43Molecular Species: ACIDHBA: 3HBD: 3#RO5 Violations: 2HBA (Lipinski): 5HBD (Lipinski): 3#RO5 Violations (Lipinski): 2CX Acidic pKa: 4.15CX Basic pKa: 3.51CX LogP: 6.11CX LogD: 3.43Aromatic Rings: 4Heavy Atoms: 37QED Weighted: 0.21Np Likeness Score: -1.03
References 1. (2015) Biphenyl derivatives useful as glucagon receptor antagonists,