3-(2,4-dihydroxyphenyl)-1-phenylprop-2-en-1-one

ID: ALA373249

Chembl Id: CHEMBL373249

PubChem CID: 6433293

Max Phase: Preclinical

Molecular Formula: C15H12O3

Molecular Weight: 240.26

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  O=C(/C=C/c1ccc(O)cc1O)c1ccccc1

Standard InChI:  InChI=1S/C15H12O3/c16-13-8-6-12(15(18)10-13)7-9-14(17)11-4-2-1-3-5-11/h1-10,16,18H/b9-7+

Standard InChI Key:  LKNPFZQVNZFLIC-VQHVLOKHSA-N

Alternative Forms

  1. Parent:

Associated Targets(Human)

Neutrophil (395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

amyS Alpha-amylase (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BMY1 Beta-amylase (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
XDH Xanthine dehydrogenase (2296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 240.26Molecular Weight (Monoisotopic): 240.0786AlogP: 2.99#Rotatable Bonds: 3
Polar Surface Area: 57.53Molecular Species: NEUTRALHBA: 3HBD: 2
#RO5 Violations: HBA (Lipinski): 3HBD (Lipinski): 2#RO5 Violations (Lipinski):
CX Acidic pKa: 8.68CX Basic pKa: CX LogP: 3.28CX LogD: 3.26
Aromatic Rings: 2Heavy Atoms: 18QED Weighted: 0.64Np Likeness Score: 0.48

References

1. Seo WD, Kim JH, Kang JE, Ryu HW, Curtis-Long MJ, Lee HS, Yang MS, Park KH..  (2005)  Sulfonamide chalcone as a new class of alpha-glucosidase inhibitors.,  15  (24): [PMID:16202584] [10.1016/j.bmcl.2005.08.087]
2. Xie Z, Luo X, Zou Z, Zhang X, Huang F, Li R, Liao S, Liu Y..  (2017)  Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia.,  27  (15): [PMID:28655421] [10.1016/j.bmcl.2017.01.053]
3. Sousa A,Lucas M,Ribeiro D,Correia CM,Silva VLM,Silva AMS,Fernandes E,Freitas M.  (2020)  Chalcones as Modulators of Neutrophil Oxidative Burst under Physiological and High Glucose Conditions.,  83  (10): [PMID:33006891] [10.1021/acs.jnatprod.0c00728]

Source