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N-(2-(6-Amino-4-(trifluoromethyl)pyridin-3-yl)-4-morpholinoquinazolin-7-yl)isonicotinamide ID: ALA3771094
Chembl Id: CHEMBL3771094
PubChem CID: 127029609
Max Phase: Preclinical
Molecular Formula: C24H20F3N7O2
Molecular Weight: 495.47
Molecule Type: Small molecule
Associated Items:
Names and Identifiers Canonical SMILES: Nc1cc(C(F)(F)F)c(-c2nc(N3CCOCC3)c3ccc(NC(=O)c4ccncc4)cc3n2)cn1
Standard InChI: InChI=1S/C24H20F3N7O2/c25-24(26,27)18-12-20(28)30-13-17(18)21-32-19-11-15(31-23(35)14-3-5-29-6-4-14)1-2-16(19)22(33-21)34-7-9-36-10-8-34/h1-6,11-13H,7-10H2,(H2,28,30)(H,31,35)
Standard InChI Key: HFCUOGDBTTWZPG-UHFFFAOYSA-N
Associated Targets(Human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 495.47Molecular Weight (Monoisotopic): 495.1631AlogP: 3.78#Rotatable Bonds: 4Polar Surface Area: 119.15Molecular Species: NEUTRALHBA: 8HBD: 2#RO5 Violations: ┄HBA (Lipinski): 9HBD (Lipinski): 3#RO5 Violations (Lipinski): ┄CX Acidic pKa: ┄CX Basic pKa: 5.21CX LogP: 3.64CX LogD: 3.64Aromatic Rings: 4Heavy Atoms: 36QED Weighted: 0.44Np Likeness Score: -1.50
References 1. Peng W, Tu ZC, Long ZJ, Liu Q, Lu G.. (2016) Discovery of 2-(2-aminopyrimidin-5-yl)-4-morpholino-N-(pyridin-3-yl)quinazolin-7-amines as novel PI3K/mTOR inhibitors and anticancer agents., 108 [PMID:26731167 ] [10.1016/j.ejmech.2015.11.038 ]