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6-(4-(Trifluoromethyl)phenyl)isoquinoline-1,3(2H,4H)-dione ID: ALA3792448
Chembl Id: CHEMBL3792448
PubChem CID: 122483635
Max Phase: Preclinical
Molecular Formula: C16H10F3NO2
Molecular Weight: 305.25
Molecule Type: Small molecule
Associated Items:
Names and Identifiers Canonical SMILES: O=C1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2C(=O)N1
Standard InChI: InChI=1S/C16H10F3NO2/c17-16(18,19)12-4-1-9(2-5-12)10-3-6-13-11(7-10)8-14(21)20-15(13)22/h1-7H,8H2,(H,20,21,22)
Standard InChI Key: JOXPXJPIHMJUBD-UHFFFAOYSA-N
Associated Targets(Human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 305.25Molecular Weight (Monoisotopic): 305.0664AlogP: 3.18#Rotatable Bonds: 1Polar Surface Area: 46.17Molecular Species: NEUTRALHBA: 2HBD: 1#RO5 Violations: ┄HBA (Lipinski): 3HBD (Lipinski): 1#RO5 Violations (Lipinski): ┄CX Acidic pKa: 7.93CX Basic pKa: ┄CX LogP: 3.20CX LogD: 3.08Aromatic Rings: 2Heavy Atoms: 22QED Weighted: 0.82Np Likeness Score: -0.62
References 1. Kankanala J, Marchand C, Abdelmalak M, Aihara H, Pommier Y, Wang Z.. (2016) Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2)., 59 (6): [PMID:26910725 ] [10.1021/acs.jmedchem.5b01973 ]