1-[[(2S)-2-[[2-[[1-[[2-[[1-[[(2S)-2-[[1-[[2-[[1-[[(2S)-2-[[1-[[2-[[1-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-6-amino-hexanoyl]amino]-6-amino-hexanoyl]amino]-6-amino-hexanoyl]amino]-6-amino-hexanoyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]cyclohexanecarbonyl]amino]acetyl]amino]cyclohexanecarbonyl]amino]-6-amino-hexanoyl]amino]cyclohexanecarbonyl]amino]acetyl]amino]cyclohexanecarbonyl]amino]-3-phenyl-propanoyl]amino]cyclohexanecarbonyl]amino]acetyl]amino]cyclohexanecarbonyl]amino]acetyl]amino]-6-amino-hexanoyl]amino]cyclohexanecarboxamide

ID: ALA3822476

PubChem CID: 127048903

Max Phase: Preclinical

Molecular Formula: C115H187N27O21

Molecular Weight: 2283.93

Molecule Type: Protein

Names and Identifiers

Canonical SMILES:  CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NC1(C(=O)NCC(=O)NC2(C(=O)N[C@@H](CCCCN)C(=O)NC3(C(=O)NCC(=O)NC4(C(=O)N[C@@H](Cc5ccccc5)C(=O)NC5(C(=O)NCC(=O)NC6(C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NC7(C(N)=O)CCCCC7)CCCCC6)CCCCC5)CCCCC4)CCCCC3)CCCCC2)CCCCC1

Standard InChI:  InChI=1S/C115H187N27O21/c1-78(143)128-82(46-16-36-66-117)95(150)132-84(48-18-38-68-119)97(152)133-83(47-17-37-67-118)96(151)131-81(45-15-35-65-116)94(149)123-73-89(144)130-87(71-79-41-11-2-12-42-79)100(155)141-112(57-27-7-28-58-112)105(160)127-76-92(147)137-114(61-31-9-32-62-114)107(162)134-86(50-20-40-70-121)99(154)140-111(55-25-6-26-56-111)104(159)126-77-93(148)138-115(63-33-10-34-64-115)108(163)135-88(72-80-43-13-3-14-44-80)101(156)142-113(59-29-8-30-60-113)106(161)125-75-91(146)136-110(53-23-5-24-54-110)103(158)124-74-90(145)129-85(49-19-39-69-120)98(153)139-109(102(122)157)51-21-4-22-52-109/h2-3,11-14,41-44,81-88H,4-10,15-40,45-77,116-121H2,1H3,(H2,122,157)(H,123,149)(H,124,158)(H,125,161)(H,126,159)(H,127,160)(H,128,143)(H,129,145)(H,130,144)(H,131,151)(H,132,150)(H,133,152)(H,134,162)(H,135,163)(H,136,146)(H,137,147)(H,138,148)(H,139,153)(H,140,154)(H,141,155)(H,142,156)/t81-,82-,83-,84-,85-,86-,87-,88-/m0/s1

Standard InChI Key:  MIIKIHNSZGOKMW-AMSGCXRISA-N

Molfile:  

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M  END

Alternative Forms

1. Parent:

   

   ALA3822476

   ---

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Protein

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 2283.93

Molecular Weight (Monoisotopic): 2282.4395

AlogP: ┄

#Rotatable Bonds: ┄

Polar Surface Area: ┄

Molecular Species: ┄

HBA: ┄

HBD: ┄

#RO5 Violations: ┄

HBA (Lipinski): ┄

HBD (Lipinski): ┄

#RO5 Violations (Lipinski): ┄

CX Acidic pKa: ┄

CX Basic pKa: ┄

CX LogP: ┄

CX LogD: ┄

Aromatic Rings: ┄

Heavy Atoms: ┄

QED Weighted: ┄

Np Likeness Score: ┄

References

1. Hicks RP..  (2016)  Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(α) amino acids.,  24  (18): [PMID:27387357] [10.1016/j.bmc.2016.06.048]

Source

Source(1):

• Scientific Literature