US8609622, 2

ID: ALA3891511

Chembl Id: CHEMBL3891511

PubChem CID: 56832787

Max Phase: Preclinical

Molecular Formula: C21H21ClF2O7

Molecular Weight: 458.84

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  COc1ccc(Cc2cc([C@@]34OC[C@@](CO)(O3)[C@@H](O)[C@H](O)[C@H]4O)ccc2Cl)c(F)c1F

Standard InChI:  InChI=1S/C21H21ClF2O7/c1-29-14-5-2-10(15(23)16(14)24)6-11-7-12(3-4-13(11)22)21-19(28)17(26)18(27)20(8-25,31-21)9-30-21/h2-5,7,17-19,25-28H,6,8-9H2,1H3/t17-,18-,19+,20+,21+/m0/s1

Standard InChI Key:  ULTLQRPKEDOYSJ-WRTQPQOASA-N

Associated Targets(non-human)

Slc5a2 Sodium/glucose cotransporter 2 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc5a1 SGLT1 protein (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 458.84Molecular Weight (Monoisotopic): 458.0944AlogP: 1.24#Rotatable Bonds: 5
Polar Surface Area: 108.61Molecular Species: NEUTRALHBA: 7HBD: 4
#RO5 Violations: HBA (Lipinski): 7HBD (Lipinski): 4#RO5 Violations (Lipinski):
CX Acidic pKa: 11.98CX Basic pKa: CX LogP: 2.25CX LogD: 2.25
Aromatic Rings: 2Heavy Atoms: 31QED Weighted: 0.53Np Likeness Score: 0.88

References

1.  (2013)  C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof, 

Source

Source(1):