3',4'-Di-O-(1''-nonyl)neamine

ID: ALA3918467

Chembl Id: CHEMBL3918467

PubChem CID: 72705274

Max Phase: Preclinical

Molecular Formula: C30H62N4O6

Molecular Weight: 574.85

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  CCCCCCCCCO[C@@H]1[C@@H](N)[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](N)C[C@@H]2N)O[C@H](CN)[C@H]1OCCCCCCCCC

Standard InChI:  InChI=1S/C30H62N4O6/c1-3-5-7-9-11-13-15-17-37-28-23(20-31)39-30(40-27-22(33)19-21(32)25(35)26(27)36)24(34)29(28)38-18-16-14-12-10-8-6-4-2/h21-30,35-36H,3-20,31-34H2,1-2H3/t21-,22+,23-,24-,25+,26-,27-,28-,29-,30-/m1/s1

Standard InChI Key:  GGAAOWZSJGLYDJ-WDEZDRLDSA-N

Alternative Forms

1. Parent:

   

   ALA3918467

   (1S,2R,3R,4S,6R)-4,6-diamino-3-[(2R,3R,4R,5R,6R)-3-amino-6-(aminomethyl)-4,5-di(nonoxy)oxan-2-yl]oxycyclohexane-1,2-diol

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 574.85

Molecular Weight (Monoisotopic): 574.4669

AlogP: 2.43

#Rotatable Bonds: 21

Polar Surface Area: 181.46

Molecular Species: BASE

HBA: 10

HBD: 6

#RO5 Violations: 2

HBA (Lipinski): 10

HBD (Lipinski): 10

#RO5 Violations (Lipinski): 2

CX Acidic pKa: 12.98

CX Basic pKa: 9.59

CX LogP: 3.09

CX LogD: -2.03

Aromatic Rings: 0

Heavy Atoms: 40

QED Weighted: 0.11

Np Likeness Score: 1.05

References

1. Zimmermann L, Das I, Désiré J, Sautrey G, Barros R S V, El Khoury M, Mingeot-Leclercq MP, Décout JL..  (2016)  New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.,  59  (20): [PMID:27690420] [10.1021/acs.jmedchem.6b00818]

2. Zimmermann L, Kempf J, Briée F, Swain J, Mingeot-Leclercq MP, Décout JL..  (2018)  Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.,  157  [PMID:30282323] [10.1016/j.ejmech.2018.08.022]

Source

Source(1):

• Scientific Literature