Standard InChI: InChI=1S/C37H56N8O11/c1-18(2)16-26(42-33(51)25(40-21(6)47)17-22-9-11-23(12-10-22)37(55)56)36(54)45-15-7-8-27(45)34(52)41-24(13-14-28(38)48)32(50)44-30(20(5)46)35(53)43-29(19(3)4)31(39)49/h9-12,18-20,24-27,29-30,46H,7-8,13-17H2,1-6H3,(H2,38,48)(H2,39,49)(H,40,47)(H,41,52)(H,42,51)(H,43,53)(H,44,50)(H,55,56)/t20-,24+,25+,26+,27-,29+,30+/m1/s1
1.Ren Z, Cabell LA, Schaefer TS, McMurray JS.. (2003) Identification of a high-affinity phosphopeptide inhibitor of Stat3., 13 (4):[PMID:12639546][10.1016/s0960-894x(02)01050-8]
2.Mandal, Pijus K PK and 9 more authors. 2009-04-23 Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling. [PMID:19334714]
3.Mandal, Pijus K; Ren, Zhiyong; Chen, Xiaomin; Xiong, Chiyi and McMurray, John S. 2009-10-08 Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3. [PMID:19728728]
4.Ioannidis, Stephanos S and 20 more authors. 2011-01-13 Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. [PMID:21138246]
5.Mandal, Pijus K and 10 more authors. 2011-05-26 Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. [PMID:21486047]
6.Ren, Xiaomei X and 8 more authors. 2010-12-09 Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. [PMID:24900231]
7.Haftchenary, Sina S and 15 more authors. 2013-11-14 Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma. [PMID:24900612]
8.LaPorte, Matthew G and 11 more authors. 2014-11-01 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. [PMID:25288188]
9.Miklossy, Gabriella G and 15 more authors. 2015-10-08 Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma. [PMID:26331426]
10.Löcken, Hauke H, Clamor, Cinzia C and Müller, Klaus K. 2018-07-27 Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells. [PMID:30003778]
11.Huang, Wei W and 8 more authors. 2018-09-05 Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. [PMID:30145375]
12.Chen, Shao-Ru SR and 7 more authors. 2018-10-01 Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice. [PMID:30228000]
13.Li, Chungen C and 8 more authors. 2019-01-15 A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3). [PMID:30472602]
14.Zhou, Haibin and 18 more authors. 2019-12-26 Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. [PMID:31747516]
15.Kaoud, Tamer S and 7 more authors. 2020-01-15 NO-releasing STAT3 inhibitors suppress BRAF-mutant melanoma growth. [PMID:31784187]
16.Cerulli, Robert A and 6 more authors. 2020-06-15 Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors. [PMID:32503696]
17.Brotherton-Pleiss, Christine and 13 more authors. 2021-01-14 Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors. [PMID:33352047]