5-(4-(4-chlorobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl)-3-(2-chlorophenyl)pyridin-2(1H)-one

ID: ALA4164548

Chembl Id: CHEMBL4164548

PubChem CID: 145959043

Max Phase: Preclinical

Molecular Formula: C29H22Cl3N3O3

Molecular Weight: 566.87

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  O=C(c1c[nH]c(=O)c(-c2ccccc2Cl)c1)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1

Standard InChI:  InChI=1S/C29H22Cl3N3O3/c30-21-9-5-18(6-10-21)26-17-34(13-14-35(26)29(38)19-7-11-22(31)12-8-19)28(37)20-15-24(27(36)33-16-20)23-3-1-2-4-25(23)32/h1-12,15-16,26H,13-14,17H2,(H,33,36)

Standard InChI Key:  OZJZXKWPMAYUHC-UHFFFAOYSA-N

Alternative Forms

  1. Parent:

    ALA4164548

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Associated Targets(Human)

EIF4A3 Tchem Eukaryotic initiation factor 4A-III (131 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 566.87Molecular Weight (Monoisotopic): 565.0727AlogP: 6.34#Rotatable Bonds: 4
Polar Surface Area: 73.48Molecular Species: NEUTRALHBA: 3HBD: 1
#RO5 Violations: 2HBA (Lipinski): 6HBD (Lipinski): 1#RO5 Violations (Lipinski): 2
CX Acidic pKa: 10.44CX Basic pKa: CX LogP: 5.28CX LogD: 5.28
Aromatic Rings: 4Heavy Atoms: 38QED Weighted: 0.31Np Likeness Score: -1.22

References

1. Mizojiri R, Nakata D, Satoh Y, Morishita D, Shibata S, Iwatani-Yoshihara M, Kosugi Y, Kosaka M, Takeda J, Sasaki S, Takami K, Fukuda K, Kamaura M, Sasaki S, Arai R, Cary DR, Imaeda Y..  (2017)  Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors.,  (10): [PMID:29057054] [10.1021/acsmedchemlett.7b00283]

Source