4-(4-Fluoro-3-(2,6-diazaspiro[3.4]octane-6-carbonyl)benzyl)-phthalazin-1(2H)-one

Names and Identifiers

Canonical SMILES: O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCC2(CNC2)C1

Standard InChI: InChI=1S/C22H21FN4O2/c23-18-6-5-14(10-19-15-3-1-2-4-16(15)20(28)26-25-19)9-17(18)21(29)27-8-7-22(13-27)11-24-12-22/h1-6,9,24H,7-8,10-13H2,(H,26,28)

Standard InChI Key: SBZYEXRPODOXGK-UHFFFAOYSA-N

Molfile:

     RDKit          2D

 29 33  0  0  0  0  0  0  0  0999 V2000
    9.8828  -11.6140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4606  -12.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0385  -11.6140    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4606  -11.0362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9248   -8.9230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9236   -9.7426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6317  -10.1515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6299   -8.5142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3385   -8.9194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3419   -9.7401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0503  -10.1452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7600   -9.7343    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7566   -8.9136    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0436   -8.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0391   -7.6868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0526  -10.9624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7614  -11.3691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7611  -12.1847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4691  -12.5912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1766  -12.1807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1718  -11.3593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4632  -10.9564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8860  -12.5864    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8769  -10.9463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5872  -11.3504    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8718  -10.1291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6779  -12.1597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4783  -12.3246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3318  -11.0106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  1  1  0
  5  6  2  0
  6  7  1  0
  7 10  2  0
  9  8  2  0
  8  5  1  0
  9 10  1  0
  9 14  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 11 16  1  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 22 17  1  0
 20 23  1  0
 21 24  1  0
 24 25  1  0
 24 26  2  0
 25 27  1  0
 27 28  1  0
 28  1  1  0
  1 29  1  0
 29 25  1  0
M  END

Alternative Forms

Parent:

ALA4166463
---

Associated Targets(Human)

PARP1 Tclin Poly [ADP-ribose] polymerase-1 (6206 Activities)

Discover Target: PARP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

MEF (1005 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Molecule Features

Natural Product: No	Oral: No	Chemical Probe: No	Parenteral: No
Molecule Type: Small molecule	Topical: No	First In Class: No	Black Box: No
Chirality: No	Availability: No	Prodrug: No

Drug Indications

MESH ID	MESH Heading	EFO IDs	EFO Terms	Max Phase for Indication	References

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Calculated Properties

Molecular Weight: 392.43	Molecular Weight (Monoisotopic): 392.1649	AlogP: 2.09	#Rotatable Bonds: 3
Polar Surface Area: 78.09	Molecular Species: BASE	HBA: 4	HBD: 2
#RO5 Violations: ┄	HBA (Lipinski): 6	HBD (Lipinski): 2	#RO5 Violations (Lipinski): ┄
CX Acidic pKa: 9.72	CX Basic pKa: 10.33	CX LogP: 0.96	CX LogD: -1.01
Aromatic Rings: 3	Heavy Atoms: 29	QED Weighted: 0.72	Np Likeness Score: -1.38

References

1. Reilly SW, Puentes LN, Wilson K, Hsieh CJ, Weng CC, Makvandi M, Mach RH.. (2018) Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity., 61 (12): [PMID:29856625] [10.1021/acs.jmedchem.8b00576]

Source

Source(1):

Scientific Literature