(S)-N-(2-(4-Cyanophenyl)benzo[d]oxazol-5-yl)-2-(2,3-difluorophenoxy)propanamide

ID: ALA4202438

Chembl Id: CHEMBL4202438

PubChem CID: 145976477

Max Phase: Preclinical

Molecular Formula: C23H15F2N3O3

Molecular Weight: 419.39

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  C[C@H](Oc1cccc(F)c1F)C(=O)Nc1ccc2oc(-c3ccc(C#N)cc3)nc2c1

Standard InChI:  InChI=1S/C23H15F2N3O3/c1-13(30-20-4-2-3-17(24)21(20)25)22(29)27-16-9-10-19-18(11-16)28-23(31-19)15-7-5-14(12-26)6-8-15/h2-11,13H,1H3,(H,27,29)/t13-/m0/s1

Standard InChI Key:  LVOFOVRHOKKPEB-ZDUSSCGKSA-N

Alternative Forms

  1. Parent:

    ALA4202438

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Associated Targets(Human)

IMPDH2 Tclin Inosine-5'-monophosphate dehydrogenase 2 (1326 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMPR2 Tbio GMP reductase 2 (49 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 419.39Molecular Weight (Monoisotopic): 419.1081AlogP: 5.05#Rotatable Bonds: 5
Polar Surface Area: 88.15Molecular Species: NEUTRALHBA: 5HBD: 1
#RO5 Violations: 1HBA (Lipinski): 6HBD (Lipinski): 1#RO5 Violations (Lipinski): 1
CX Acidic pKa: 12.37CX Basic pKa: 0.10CX LogP: 4.81CX LogD: 4.81
Aromatic Rings: 4Heavy Atoms: 31QED Weighted: 0.49Np Likeness Score: -2.09

References

1. Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L..  (2018)  Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.,  61  (11): [PMID:29746130] [10.1021/acs.jmedchem.7b01839]

Source