ID: ALA4228804

Max Phase: Preclinical

Molecular Formula: C25H18ClF5N4O2

Molecular Weight: 536.89

Molecule Type: Small molecule

Representations

Canonical SMILES:  CC1(C)Cc2c(c(C(=O)Nc3cc(C(F)(F)F)ccc3F)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1

Standard InChI:  InChI=1S/C25H18ClF5N4O2/c1-24(2)10-13-19-18(33-23(34-19)35-20-14(26)4-3-5-16(20)28)9-12(21(13)37-24)22(36)32-17-8-11(25(29,30)31)6-7-15(17)27/h3-9H,10H2,1-2H3,(H,32,36)(H2,33,34,35)

Standard InChI Key:  DNVUWMRRGUVVRF-UHFFFAOYSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Properties

Molecular Weight: 536.89

Molecular Weight (Monoisotopic): 536.1038

AlogP: 7.22

#Rotatable Bonds: 4

Polar Surface Area: 79.04

Molecular Species: NEUTRAL

HBA: 4

HBD: 3

#RO5 Violations: 2

HBA (Lipinski): 6

HBD (Lipinski): 3

#RO5 Violations (Lipinski): 2

CX Acidic pKa: 11.36

CX Basic pKa: 6.11

CX LogP: 6.82

CX LogD: 6.80

Aromatic Rings: 4

Heavy Atoms: 37

QED Weighted: 0.24

Np Likeness Score: -1.33

References

1. Muthukaman N, Deshmukh S, Tambe M, Pisal D, Tondlekar S, Shaikh M, Sarode N, Kattige VG, Sawant P, Pisat M, Karande V, Honnegowda S, Kulkarni A, Behera D, Jadhav SB, Sangana RR, Gudi GS, Khairatkar-Joshi N, Gharat LA..  (2018)  Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2.,  28  (7): [PMID:29519738] [10.1016/j.bmcl.2018.02.048]

Source

Source(1):

• Scientific Literature