Standard InChI: InChI=1S/C21H25N3O3Si/c1-6-27-21(26)19-18-13-23(2)20(25)16-12-15(8-7-11-28(3,4)5)9-10-17(16)24(18)14-22-19/h9-10,12,14H,6,11,13H2,1-5H3
GABA A receptor alpha-2/beta-2/gamma-2 194 Activities
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GABA A receptor alpha-3/beta-2/gamma-2 101 Activities
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GABA A receptor alpha-6/beta-2/gamma-2 27 Activities
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Molecule Features
Natural Product: No
Oral: No
Chemical Probe: No
Parenteral: No
Molecule Type: Small molecule
Topical: No
First In Class: No
Black Box: No
Chirality: No
Availability: No
Prodrug: No
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Properties
Molecular Weight: 395.54
Molecular Weight (Monoisotopic): 395.1665
AlogP:
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References
1.Liu R, Hu RJ, Zhang P, Skolnick P, Cook JM.. (1996) Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors., 39 (9):[PMID:8627617][10.1021/jm950887n]
2.Huang Q, Liu R, Zhang P, He X, McKernan R, Gan T, Bennett DW, Cook JM.. (1998) Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis., 41 (21):[PMID:9767648][10.1021/jm980317y]
3.Huang Q, He X, Ma C, Liu R, Yu S, Dayer CA, Wenger GR, McKernan R, Cook JM.. (2000) Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach., 43 (1):[PMID:10633039][10.1021/jm990341r]
