| 1. Matsuda A, Takenuki K, Sasaki T, Ueda T.. (1991) Nucleosides and nucleotides. 94. Radical deoxygenation of tert-alcohols in 1-(2-C-alkylpentofuranosyl) pyrimidines: synthesis of (2'S)-2'-deoxy-2'-C-methylcytidine, an antileukemic nucleoside., 34 (1): [PMID:1992123] [10.1021/jm00105a037] |
| 2. Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW.. (2005) Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication., 48 (17): [PMID:16107149] [10.1021/jm0502788] |
| 3. Pierra C, Amador A, Benzaria S, Cretton-Scott E, D'Amours M, Mao J, Mathieu S, Moussa A, Bridges EG, Standring DN, Sommadossi JP, Storer R, Gosselin G.. (2006) Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine., 49 (22): [PMID:17064080] [10.1021/jm0603623] |
| 4. Murakami E, Bao H, Ramesh M, McBrayer TR, Whitaker T, Micolochick Steuer HM, Schinazi RF, Stuyver LJ, Obikhod A, Otto MJ, Furman PA.. (2007) Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase., 51 (2): [PMID:17101674] [10.1128/aac.00400-06] |
| 5. Smith DB, Martin JA, Klumpp K, Baker SJ, Blomgren PA, Devos R, Granycome C, Hang J, Hobbs CJ, Jiang WR, Laxton C, Le Pogam S, Leveque V, Ma H, Maile G, Merrett JH, Pichota A, Sarma K, Smith M, Swallow S, Symons J, Vesey D, Najera I, Cammack N.. (2007) Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479., 17 (9): [PMID:17317178] [10.1016/j.bmcl.2007.02.004] |
| 6. Kim HJ, Sharon A, Bal C, Wang J, Allu M, Huang Z, Murray MG, Bassit L, Schinazi RF, Korba B, Chu CK.. (2009) Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro., 52 (1): [PMID:19072694] [10.1021/jm801418v] |
| 7. Murakami E, Niu C, Bao H, Micolochick Steuer HM, Whitaker T, Nachman T, Sofia MA, Wang P, Otto MJ, Furman PA.. (2008) The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase., 52 (2): [PMID:17999967] [10.1128/aac.01184-07] |
| 8. Gardelli C, Attenni B, Donghi M, Meppen M, Pacini B, Harper S, Di Marco A, Fiore F, Giuliano C, Pucci V, Laufer R, Gennari N, Marcucci I, Leone JF, Olsen DB, MacCoss M, Rowley M, Narjes F.. (2009) Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection., 52 (17): [PMID:19725579] [10.1021/jm900447q] |
| 9. McCown MF, Rajyaguru S, Le Pogam S, Ali S, Jiang WR, Kang H, Symons J, Cammack N, Najera I.. (2008) The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors., 52 (5): [PMID:18285474] [10.1128/aac.01317-07] |
| 10. Korba BE, Elazar M, Lui P, Rossignol JF, Glenn JS.. (2008) Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide., 52 (11): [PMID:18710916] [10.1128/aac.00078-08] |
| 11. Jonckers TH, Lin TI, Buyck C, Lachau-Durand S, Vandyck K, Van Hoof S, Vandekerckhove LA, Hu L, Berke JM, Vijgen L, Dillen LL, Cummings MD, de Kock H, Nilsson M, Sund C, Rydegård C, Samuelsson B, Rosenquist A, Fanning G, Van Emelen K, Simmen K, Raboisson P.. (2010) 2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase., 53 (22): [PMID:21033671] [10.1021/jm101050a] |
| 12. Herlihy KJ, Graham JP, Kumpf R, Patick AK, Duggal R, Shi ST.. (2008) Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors., 52 (10): [PMID:18694956] [10.1128/aac.00533-08] |
| 13. Coelmont L, Kaptein S, Paeshuyse J, Vliegen I, Dumont JM, Vuagniaux G, Neyts J.. (2009) Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors., 53 (3): [PMID:19104013] [10.1128/aac.00939-08] |
| 14. Paeshuyse J, Vliegen I, Coelmont L, Leyssen P, Tabarrini O, Herdewijn P, Mittendorfer H, Easmon J, Cecchetti V, Bartenschlager R, Puerstinger G, Neyts J.. (2008) Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors., 52 (9): [PMID:18625766] [10.1128/aac.01534-07] |
| 15. Flint M, Mullen S, Deatly AM, Chen W, Miller LZ, Ralston R, Broom C, Emini EA, Howe AY.. (2009) Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034)., 53 (2): [PMID:18936191] [10.1128/aac.01081-08] |
| 16. Gadthula S, Rawal RK, Sharon A, Wu D, Korba B, Chu CK.. (2011) Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus., 21 (13): [PMID:21621997] [10.1016/j.bmcl.2011.05.012] |
| 17. Moura M, Josse S, Nguyen Van Nhien A, Fournier C, Duverlie G, Castelain S, Soriano E, Marco-Contelles J, Balzarini J, Postel D.. (2011) Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV., 46 (10): [PMID:21880398] [10.1016/j.ejmech.2011.08.017] |
| 18. Carta A, Briguglio I, Piras S, Corona P, Boatto G, Nieddu M, Giunchedi P, Marongiu ME, Giliberti G, Iuliano F, Blois S, Ibba C, Busonera B, La Colla P.. (2011) Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors., 19 (23): [PMID:22047799] [10.1016/j.bmc.2011.10.009] |
| 19. Shi J, Zhou L, Zhang H, McBrayer TR, Detorio MA, Johns M, Bassit L, Powdrill MH, Whitaker T, Coats SJ, Götte M, Schinazi RF.. (2011) Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates., 21 (23): [PMID:22014549] [10.1016/j.bmcl.2011.09.089] |
| 20. Sála M, Hřebabecký H, Leyssen P, Dejmek M, Dračínský M, De Palma AM, Neyts J, Nencka R.. (2012) Novel substituted 9-norbornylpurines and their activities against RNA viruses., 22 (5): [PMID:22310228] [10.1016/j.bmcl.2012.01.040] |
| 21. Cho A, Zhang L, Xu J, Babusis D, Butler T, Lee R, Saunders OL, Wang T, Parrish J, Perry J, Feng JY, Ray AS, Kim CU.. (2012) Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors., 22 (12): [PMID:22578461] [10.1016/j.bmcl.2012.04.065] |
| 22. Vitale G, Corona P, Loriga M, Carta A, Paglietti G, Giliberti G, Sanna G, Farci P, Marongiu ME, La Colla P.. (2012) 5-acetyl-2-arylbenzimidazoles as antiviral agents. Part 4., 53 [PMID:22513121] [10.1016/j.ejmech.2012.03.038] |
| 23. Abou-Elkhair RA, Moustafa AH, Haikal AZ, Ibraheem AM.. (2014) Synthesis and biological evaluation of 2-oxonicotinonitriles and 2-oxonicotinonitrile based nucleoside analogues., 74 [PMID:24486419] [10.1016/j.ejmech.2013.12.055] |
| 24. Jonckers TH, Vandyck K, Vandekerckhove L, Hu L, Tahri A, Van Hoof S, Lin TI, Vijgen L, Berke JM, Lachau-Durand S, Stoops B, Leclercq L, Fanning G, Samuelsson B, Nilsson M, Rosenquist Å, Simmen K, Raboisson P.. (2014) Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase., 57 (5): [PMID:24345201] [10.1021/jm4015422] |
| 25. Mish MR, Cho A, Kirschberg T, Xu J, Zonte CS, Fenaux M, Park Y, Babusis D, Feng JY, Ray AS, Kim CU.. (2014) Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors., 24 (14): [PMID:24907145] [10.1016/j.bmcl.2014.05.015] |
| 26. Loddo R, Briguglio I, Corona P, Piras S, Loriga M, Paglietti G, Carta A, Sanna G, Giliberti G, Ibba C, Farci P, La Colla P.. (2014) Synthesis and antiviral activity of new phenylimidazopyridines and N-benzylidenequinolinamines derived by molecular simplification of phenylimidazo[4,5-g]quinolines., 84 [PMID:25014745] [10.1016/j.ejmech.2014.07.011] |
| 27. Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU.. (2015) Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors., 25 (5): [PMID:25650256] [10.1016/j.bmcl.2015.01.021] |
| 28. Fioravanti R, Desideri N, Biava M, Droghini P, Atzori EM, Ibba C, Collu G, Sanna G, Delogu I, Loddo R.. (2015) N-((1,3-Diphenyl-1H-pyrazol-4-yl)methyl)anilines: A novel class of anti-RSV agents., 25 (11): [PMID:25913116] [10.1016/j.bmcl.2015.04.006] |
| 29. Bielenica A, Stefańska J, Stępień K, Napiórkowska A, Augustynowicz-Kopeć E, Sanna G, Madeddu S, Boi S, Giliberti G, Wrzosek M, Struga M.. (2015) Synthesis, cytotoxicity and antimicrobial activity of thiourea derivatives incorporating 3-(trifluoromethyl)phenyl moiety., 101 [PMID:26119992] [10.1016/j.ejmech.2015.06.027] |
| 30. Briguglio I, Loddo R, Laurini E, Fermeglia M, Piras S, Corona P, Giunchedi P, Gavini E, Sanna G, Giliberti G, Ibba C, Farci P, La Colla P, Pricl S, Carta A.. (2015) Synthesis, cytotoxicity and antiviral evaluation of new series of imidazo[4,5-g]quinoline and pyrido[2,3-g]quinoxalinone derivatives., 105 [PMID:26479028] [10.1016/j.ejmech.2015.10.002] |
| 31. Kim Y, Galasiti Kankanamalage AC, Chang KO, Groutas WC.. (2015) Recent Advances in the Discovery of Norovirus Therapeutics., 58 (24): [PMID:26258852] [10.1021/acs.jmedchem.5b00762] |
| 32. Cheng YB, Lee JC, Lo IW, Chen SR, Hu HC, Wu YH, Wu YC, Chang FR.. (2016) Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2., 26 (9): [PMID:26988299] [10.1016/j.bmcl.2016.03.029] |
| 33. Carta A, Briguglio I, Piras S, Corona P, Ibba R, Laurini E, Fermeglia M, Pricl S, Desideri N, Atzori EM, La Colla P, Collu G, Delogu I, Loddo R.. (2016) A combined in silico/in vitro approach unveils common molecular requirements for efficient BVDV RdRp binding of linear aromatic N-polycyclic systems., 117 [PMID:27161176] [10.1016/j.ejmech.2016.03.080] |
| 34. Zhou S, Mahmoud S, Liu P, Zhou L, Ehteshami M, Bassit L, Tao S, Domaoal RA, Sari O, Schutter C, Amiralaei S, Khalil A, Ollinger Russell O, McBrayer T, Whitaker T, Abou-Taleb N, Amblard F, Coats SJ, Schinazi RF.. (2017) 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture., 60 (13): [PMID:28595015] [10.1021/acs.jmedchem.7b00067] |
| 35. Harmalkar DS, Lee SJ, Lu Q, Kim MI, Park J, Lee H, Park M, Lee A, Lee C, Lee K.. (2019) Identification of novel non-nucleoside vinyl-stilbene analogs as potent norovirus replication inhibitors with a potential host-targeting mechanism., 184 [PMID:31604163] [10.1016/j.ejmech.2019.111733] |
| 36. Mengshetti S, Zhou L, Sari O, De Schutter C, Zhang H, Cho JH, Tao S, Bassit LC, Verma K, Domaoal RA, Ehteshami M, Jiang Y, Ovadia R, Kasthuri M, Ollinger Russell O, McBrayer T, Whitaker T, Pattassery J, Pascual ML, Uher L, Lin BY, Lee S, Amblard F, Coats SJ, Schinazi RF.. (2019) Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus., 62 (4): [PMID:30653317] [10.1021/acs.jmedchem.8b01300] |
| 37. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
| 38. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
| 39. Li Q,Groaz E,Rocha-Pereira J,Neyts J,Herdewijn P. (2020) Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides., 195 [PMID:32294613] [10.1016/j.ejmech.2020.112198] |
| 40. Haverkamp C, Liu C, Schneller SW.. (2021) Enantiomeric 4'-truncated 6'-fluoro-3-deazaneplanocin and its 3-bromo derivative: Synthesis and antiviral properties, including Ebola and Marburg., 41 [PMID:33766766] [10.1016/j.bmcl.2021.127985] |
| 41. Nascimento IJDS, Santos-Júnior PFDS, Aquino TM, Araújo-Júnior JX, Silva-Júnior EFD.. (2021) Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors., 224 [PMID:34274831] [10.1016/j.ejmech.2021.113698] |
| 42. Liu C, Chen Q, Schneller SW.. (2023) 2- and 3-Fluoro-3-deaza-1',6'-isoneplanocin: Synthesis and antiviral properties (including Ebola and Marburg)., 85 [PMID:36898483] [10.1016/j.bmcl.2023.129219] |
