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32. USP Dictionary of USAN and International Names (2010 edition) and USAN registrations 2007-date, |
33. Singh A, Dirain M, Witek R, Rocca JR, Edison AS, Haskell-Luevano C.. (2013) Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R)., 56 (7): [PMID:23432160] [10.1021/jm301253y] |
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37. Haslach EM, Huang H, Dirain M, Debevec G, Geer P, Santos RG, Giulianotti MA, Pinilla C, Appel JR, Doering SR, Walters MA, Houghten RA, Haskell-Luevano C.. (2014) Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs)., 57 (11): [PMID:24517312] [10.1021/jm500064t] |
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40. Lensing CJ, Freeman KT, Schnell SM, Adank DN, Speth RC, Haskell-Luevano C.. (2016) An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers., 59 (7): [PMID:26959173] [10.1021/acs.jmedchem.5b01894] |
41. WHO Anatomical Therapeutic Chemical Classification, |
42. Gunia-Krzyżak A, Żelaszczyk D, Rapacz A, Żesławska E, Waszkielewicz AM, Pańczyk K, Słoczyńska K, Pękala E, Nitek W, Filipek B, Marona H.. (2017) Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3., 25 (2): [PMID:27876250] [10.1016/j.bmc.2016.11.014] |
43. Ericson MD, Freeman KT, Schnell SM, Haskell-Luevano C.. (2017) A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands., 60 (2): [PMID:28045525] [10.1021/acs.jmedchem.6b01707] |
44. Palmer D, Gonçalves JPL, V Hansen L, Wu B, Hald H, Schoffelen S, Diness F, Le Quement ST, Nielsen TE, Meldal M.. (2017) Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists., 60 (21): [PMID:28972753] [10.1021/acs.jmedchem.7b00353] |
45. Ericson MD, Freeman KT, Schnell SM, Fleming KA, Haskell-Luevano C.. (2017) Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor., 60 (19): [PMID:28813605] [10.1021/acs.jmedchem.7b00856] |
46. Ericson MD, Singh A, Tala SR, Haslach EM, Dirain MLS, Schaub JW, Flores V, Eick N, Lensing CJ, Freeman KT, Smeester BA, Adank DN, Wilber SL, Speth R, Haskell-Luevano C.. (2018) Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors., 61 (8): [PMID:29578343] [10.1021/acs.jmedchem.8b00251] |
47. Doering SR, Freeman KT, Schnell SM, Haslach EM, Dirain M, Debevec G, Geer P, Santos RG, Giulianotti MA, Pinilla C, Appel JR, Speth RC, Houghten RA, Haskell-Luevano C.. (2017) Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2., 60 (10): [PMID:28453292] [10.1021/acs.jmedchem.7b00301] |
48. Fleming KA, Freeman KT, Ericson MD, Haskell-Luevano C.. (2018) Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists., 61 (17): [PMID:30035543] [10.1021/acs.jmedchem.8b00684] |
49. Unpublished dataset, |
50. Winget MD, Ericson MD, Freeman KT, Haskell-Luevano C.. (2020) Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy., 11 (3): [PMID:32184956] [10.1021/acsmedchemlett.9b00198] |
51. Koerperich ZM, Ericson MD, Freeman KT, Speth RC, Pogozheva ID, Mosberg HI, Haskell-Luevano C.. (2020) Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists., 63 (5): [PMID:31845801] [10.1021/acs.jmedchem.9b00860] |
52. Fleming KA, Freeman KT, Powers MD, Santos RG, Debevec G, Giulianotti MA, Houghten RA, Doering SR, Pinilla C, Haskell-Luevano C.. (2019) Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μM MC4R Partial Agonist., 62 (5): [PMID:30741545] [10.1021/acs.jmedchem.9b00053] |
53. Unpublished dataset, |
54. Ericson MD,Shaikh R,Larson CM,Freeman KT,Haskell-Luevano C. (2021) Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist., 12 (1): [PMID:33488972] [10.1021/acsmedchemlett.0c00561] |
55. Yuan S,Yu B,Liu HM. (2020) New drug approvals for 2019: Synthesis and clinical applications., 205 [PMID:32911308] [10.1016/j.ejmech.2020.112667] |
56. Ericson MD,Freeman KT,Haskell-Luevano C. (2020) Peptoid NPhe in AGRP-Based c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Scaffolds Maintain Mouse MC4R Antagonist Potency., 11 (10): [PMID:33062177] [10.1021/acsmedchemlett.9b00641] |
57. Ericson MD, Doering SR, Larson CM, Freeman KT, LaVoi TM, Donow HM, Santos RG, Cho RH, Koerperich ZM, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C.. (2021) Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist., 64 (19.0): [PMID:34592820] [10.1021/acs.jmedchem.1c01417] |
58. Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C.. (2021) Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign., 64 (9.0): [PMID:33886285] [10.1021/acs.jmedchem.0c02041] |