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11-epi-sinulariolide acetate ID: ALA4464558
Chembl Id: CHEMBL4464558
PubChem CID: 100914611
Max Phase: Preclinical
Molecular Formula: C22H32O5
Molecular Weight: 376.49
Molecule Type: Unknown
Associated Items:
Names and Identifiers Canonical SMILES: C=C1C(=O)O[C@]2(C)CC[C@@H]1C[C@@H]1O[C@@]1(C)CC/C=C(\C)CC[C@H]2OC(C)=O
Standard InChI: InChI=1S/C22H32O5/c1-14-7-6-11-21(4)19(26-21)13-17-10-12-22(5,27-20(24)15(17)2)18(9-8-14)25-16(3)23/h7,17-19H,2,6,8-13H2,1,3-5H3/b14-7+/t17-,18-,19+,21+,22-/m1/s1
Standard InChI Key: OEGFAXMPAOHOCK-RAVJQKOMSA-N
Associated Targets(Human) Associated Targets(non-human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: UnknownTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 376.49Molecular Weight (Monoisotopic): 376.2250AlogP: 4.25#Rotatable Bonds: 1Polar Surface Area: 65.13Molecular Species: NEUTRALHBA: 5HBD: ┄#RO5 Violations: ┄HBA (Lipinski): 5HBD (Lipinski): ┄#RO5 Violations (Lipinski): ┄CX Acidic pKa: ┄CX Basic pKa: ┄CX LogP: 4.11CX LogD: 4.11Aromatic Rings: ┄Heavy Atoms: 27QED Weighted: 0.30Np Likeness Score: 3.44
References 1. Wu Q, Li XW, Li H, Yao LG, Tang W, Miao ZH, Wang H, Guo YW.. (2019) Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis., 29 (2): [PMID:30528697 ] [10.1016/j.bmcl.2018.12.004 ]