(5S,8S,11S,14S,17S)-1-amino-8,11,14-tris(4-aminobutyl)-17-(hydroxymethyl)-7,10,13,16,19,27-hexaoxo-20-palmitamido-24-(palmitoyloxy)-26-oxa-22-thia-6,9,12,15,18-pentaazadotetracontane-5-carboxylic acid

ID: ALA4470462

Chembl Id: CHEMBL4470462

PubChem CID: 155534646

Max Phase: Preclinical

Molecular Formula: C81H156N10O13S

Molecular Weight: 1510.26

Molecule Type: Unknown

Names and Identifiers

Canonical SMILES:  CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O

Standard InChI:  InChI=1S/C81H156N10O13S/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-55-73(93)86-72(65-105-64-66(104-75(95)57-42-39-36-33-30-27-24-21-18-15-12-9-6-3)63-103-74(94)56-41-38-35-32-29-26-23-20-17-14-11-8-5-2)80(100)91-71(62-92)79(99)89-68(52-44-48-59-83)77(97)87-67(51-43-47-58-82)76(96)88-69(53-45-49-60-84)78(98)90-70(81(101)102)54-46-50-61-85/h66-72,92H,4-65,82-85H2,1-3H3,(H,86,93)(H,87,97)(H,88,96)(H,89,99)(H,90,98)(H,91,100)(H,101,102)/t66?,67-,68-,69-,70-,71-,72?/m0/s1

Standard InChI Key:  OEDPHAKKZGDBEV-HJHJJFTHSA-N

Alternative Forms

1. Parent:

   

   ALA4470462

   ---

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Unknown

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 1510.26

Molecular Weight (Monoisotopic): 1509.1574

AlogP: ┄

#Rotatable Bonds: ┄

Polar Surface Area: ┄

Molecular Species: ┄

HBA: ┄

HBD: ┄

#RO5 Violations: ┄

HBA (Lipinski): ┄

HBD (Lipinski): ┄

#RO5 Violations (Lipinski): ┄

CX Acidic pKa: ┄

CX Basic pKa: ┄

CX LogP: ┄

CX LogD: ┄

Aromatic Rings: ┄

Heavy Atoms: ┄

QED Weighted: ┄

Np Likeness Score: ┄

References

1. Su L, Wang Y, Wang J, Mifune Y, Morin MD, Jones BT, Moresco EMY, Boger DL, Beutler B, Zhang H..  (2019)  Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim.,  62  (6): [PMID:30829478] [10.1021/acs.jmedchem.8b01583]

Source

Source(1):

• Scientific Literature