ID: ALA449831

Max Phase: Preclinical

Molecular Formula: C34H30N4O11

Molecular Weight: 670.63

Molecule Type: Small molecule

Representations

Canonical SMILES:  O=C1c2c(c3c4ccc(O)cc4n(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c3c3[nH]c4cc(O)ccc4c23)C(=O)N1NCc1cccc(CO)c1

Standard InChI:  InChI=1S/C34H30N4O11/c39-12-15-3-1-2-14(8-15)11-35-37-32(46)25-23-18-6-4-16(41)9-20(18)36-27(23)28-24(26(25)33(37)47)19-7-5-17(42)10-21(19)38(28)49-34-31(45)30(44)29(43)22(13-40)48-34/h1-10,22,29-31,34-36,39-45H,11-13H2/t22-,29-,30+,31-,34+/m1/s1

Standard InChI Key:  OJSXVODGEDAEIJ-IWCRPMNOSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Properties

Molecular Weight: 670.63

Molecular Weight (Monoisotopic): 670.1911

AlogP: 0.86

#Rotatable Bonds: 7

Polar Surface Area: 230.20

Molecular Species: NEUTRAL

HBA: 13

HBD: 9

#RO5 Violations: 3

HBA (Lipinski): 15

HBD (Lipinski): 9

#RO5 Violations (Lipinski): 3

CX Acidic pKa: 8.75

CX Basic pKa: 2.82

CX LogP: 0.50

CX LogD: 0.48

Aromatic Rings: 6

Heavy Atoms: 49

QED Weighted: 0.11

Np Likeness Score: 0.75

References

1. Sunami S, Nishimura T, Nishimura I, Ito S, Arakawa H, Ohkubo M..  (2009)  Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin.,  52  (10): [PMID:19397324] [10.1021/jm801641t]

Source

Source(1):

• Scientific Literature