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(S)-N-(1-((5-(N-(tert-butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-chlorobenzamide ID: ALA4515353
Chembl Id: CHEMBL4515353
PubChem CID: 146503455
Max Phase: Preclinical
Molecular Formula: C30H30ClN3O4S
Molecular Weight: 564.11
Molecule Type: Unknown
Associated Items:
Names and Identifiers Canonical SMILES: CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)c3ccc(Cl)cc3)cccc12
Standard InChI: InChI=1S/C30H30ClN3O4S/c1-30(2,3)34-39(37,38)27-14-8-11-23-24(27)12-7-13-25(23)32-29(36)26(19-20-9-5-4-6-10-20)33-28(35)21-15-17-22(31)18-16-21/h4-18,26,34H,19H2,1-3H3,(H,32,36)(H,33,35)/t26-/m0/s1
Standard InChI Key: XRQFZJZKMGOLOB-SANMLTNESA-N
Associated Targets(Human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: UnknownTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 564.11Molecular Weight (Monoisotopic): 563.1646AlogP: 5.55#Rotatable Bonds: 8Polar Surface Area: 104.37Molecular Species: NEUTRALHBA: 4HBD: 3#RO5 Violations: 2HBA (Lipinski): 7HBD (Lipinski): 3#RO5 Violations (Lipinski): 2CX Acidic pKa: 9.88CX Basic pKa: ┄CX LogP: 5.66CX LogD: 5.66Aromatic Rings: 4Heavy Atoms: 39QED Weighted: 0.26Np Likeness Score: -1.21
References 1. (2018) Usp30 inhibitors, 2. Kluge AF,Lagu BR,Maiti P,Jaleel M,Webb M,Malhotra J,Mallat A,Srinivas PA,Thompson JE. (2018) Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy., 28 (15): [PMID:29935771 ] [10.1016/j.bmcl.2018.05.013 ]