(S)-N4-tert-butyl-N1-(2-(3-isopropylbenzamido)ethyl)-2-(4-methylphenylsulfonamido)succinamide

ID: ALA4537720

Chembl Id: CHEMBL4537720

PubChem CID: 155548324

Max Phase: Preclinical

Molecular Formula: C27H38N4O5S

Molecular Weight: 530.69

Molecule Type: Unknown

Associated Items:

Names and Identifiers

Canonical SMILES:  Cc1ccc(S(=O)(=O)N[C@@H](CC(=O)NC(C)(C)C)C(=O)NCCNC(=O)c2cccc(C(C)C)c2)cc1

Standard InChI:  InChI=1S/C27H38N4O5S/c1-18(2)20-8-7-9-21(16-20)25(33)28-14-15-29-26(34)23(17-24(32)30-27(4,5)6)31-37(35,36)22-12-10-19(3)11-13-22/h7-13,16,18,23,31H,14-15,17H2,1-6H3,(H,28,33)(H,29,34)(H,30,32)/t23-/m0/s1

Standard InChI Key:  XUEKNKSFBFWPFA-QHCPKHFHSA-N

Alternative Forms

  1. Parent:

    ALA4537720

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Associated Targets(Human)

PSMB5 Tclin Proteasome Macropain subunit MB1 (2451 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PSMB8 Tclin Proteasome subunit beta type-8 (743 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Karpas-1106P (27 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: UnknownTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 530.69Molecular Weight (Monoisotopic): 530.2563AlogP: 2.62#Rotatable Bonds: 11
Polar Surface Area: 133.47Molecular Species: NEUTRALHBA: 5HBD: 4
#RO5 Violations: 1HBA (Lipinski): 9HBD (Lipinski): 4#RO5 Violations (Lipinski): 1
CX Acidic pKa: 10.36CX Basic pKa: CX LogP: 2.73CX LogD: 2.73
Aromatic Rings: 2Heavy Atoms: 37QED Weighted: 0.33Np Likeness Score: -1.19

References

1. Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK, Rosenthal PJ, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G..  (2019)  Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors.,  62  (13): [PMID:31177777] [10.1021/acs.jmedchem.9b00363]

Source