| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ID: ALA4557180
Max Phase: Preclinical
Molecular Formula: C46H75F4N11O9S2
Molecular Weight: 1066.30
Molecule Type: Unknown
Associated Items:
Representations
Canonical SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSc2c(F)c(F)c(c(F)c2F)SC[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(N)=O
Standard InChI: InChI=1S/C46H75F4N11O9S2/c1-8-23(6)35(39(54)63)60-44(68)29(18-22(4)5)57-41(65)26(13-9-11-15-51)56-45(69)30-20-72-38-33(49)31(47)37(32(48)34(38)50)71-19-25(53)40(64)61-36(24(7)62)46(70)58-28(17-21(2)3)43(67)55-27(42(66)59-30)14-10-12-16-52/h21-30,35-36,62H,8-20,51-53H2,1-7H3,(H2,54,63)(H,55,67)(H,56,69)(H,57,65)(H,58,70)(H,59,66)(H,60,68)(H,61,64)/t23-,24+,25-,26-,27-,28-,29-,30-,35-,36-/m0/s1
Standard InChI Key: HRCAQNNGYBGBCN-FBMPNZRISA-N
Associated Targets(Human)
L-lactate dehydrogenase B chain 463 Activities
L-lactate dehydrogenase A chain 1573 Activities
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Associated Targets(non-human)
L-lactate dehydrogenase B chain 2 Activities
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Molecule Features
| Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
| Molecule Type: Unknown | Topical: No | First In Class: No | Black Box: No |
| Chirality: No | Availability: No | Prodrug: No |
Drug Indications
| MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Properties
| Molecular Weight: 1066.30 | Molecular Weight (Monoisotopic): 1065.5127 | AlogP: | #Rotatable Bonds: |
| Polar Surface Area: | Molecular Species: | HBA: | HBD: |
| #RO5 Violations: | HBA (Lipinski): | HBD (Lipinski): | #RO5 Violations (Lipinski): |
| CX Acidic pKa: | CX Basic pKa: | CX LogP: | CX LogD: |
| Aromatic Rings: | Heavy Atoms: | QED Weighted: | Np Likeness Score: |
References
| 1. Thabault L, Brisson L, Brustenga C, Martinez Gache SA, Prévost JRC, Kozlova A, Spillier Q, Liberelle M, Benyahia Z, Messens J, Copetti T, Sonveaux P, Frédérick R.. (2020) Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides., 63 (9): [PMID:32250117] [10.1021/acs.jmedchem.9b01955] |
Source
Source(1):