Standard InChI: InChI=1S/C16H30N2O5/c1-5-6-7-8-12(10-14(19)18-22)15(20)17-13(9-11(2)3)16(21)23-4/h11-13,22H,5-10H2,1-4H3,(H,17,20)(H,18,19)/t12-,13-/m0/s1
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3.Sun, Wei and 9 more authors. 2009-02-12 Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. [PMID:19138149]
4.Cohen, Frederick F and 12 more authors. 2009-03-26 Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. [PMID:19228017]
5.Sun, Haiying and 6 more authors. 2010-05-15 Cyclopeptide Smac mimetics as antagonists of IAP proteins. [PMID:20443226]
6.Cai, Qian and 17 more authors. 2011-04-28 A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. [PMID:21443232]
7.Sun, Haiying and 11 more authors. 2011-05-12 Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. [PMID:21462933]
8.Flygare, John A JA and 41 more authors. 2012-05-10 Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). [PMID:22413863]
9.Allensworth, Jennifer L JL, Sauer, Scott J SJ, Lyerly, H Kim HK, Morse, Michael A MA and Devi, Gayathri R GR. 2013-01 Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism. [PMID:23225169]
10.Sheng, Rong R and 13 more authors. 2013-05-23 A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. [PMID:23651223]
11.Donnell, Andrew F AF and 28 more authors. 2013-10-24 Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain. [PMID:24083782]
12.Kester, Robert F RF and 31 more authors. 2013-10-24 Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain. [PMID:24093940]
13.Perez, Heidi L HL and 14 more authors. 2015-02-12 Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity. [PMID:25584393]
14.Tamanini, Emiliano E and 18 more authors. 2017-06-08 Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). [PMID:28492317]
15.Baggio, Carlo C and 8 more authors. 2018-07-26 Design of Potent pan-IAP and Lys-Covalent XIAP Selective Inhibitors Using a Thermodynamics Driven Approach. [PMID:29940121]