N-(1,2,3,4-tetrahydronaphthalen-1-yl)formamide

ID: ALA4794084

Chembl Id: CHEMBL4794084

Cas Number: 62089-81-0

PubChem CID: 4165105

Max Phase: Preclinical

Molecular Formula: C11H13NO

Molecular Weight: 175.23

Molecule Type: Unknown

Associated Items:

Names and Identifiers

Canonical SMILES:  O=CNC1CCCc2ccccc21

Standard InChI:  InChI=1S/C11H13NO/c13-8-12-11-7-3-5-9-4-1-2-6-10(9)11/h1-2,4,6,8,11H,3,5,7H2,(H,12,13)

Standard InChI Key:  SXEPYAAYPZBIEE-UHFFFAOYSA-N

Alternative Forms

Associated Targets(Human)

EPHX1 Tchem Epoxide hydrolase 1 (644 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: UnknownTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 175.23Molecular Weight (Monoisotopic): 175.0997AlogP: 1.81#Rotatable Bonds: 2
Polar Surface Area: 29.10Molecular Species: NEUTRALHBA: 1HBD: 1
#RO5 Violations: HBA (Lipinski): 2HBD (Lipinski): 1#RO5 Violations (Lipinski):
CX Acidic pKa: CX Basic pKa: CX LogP: 1.86CX LogD: 1.86
Aromatic Rings: 1Heavy Atoms: 13QED Weighted: 0.68Np Likeness Score: 0.10

References

1. Barnych B,Singh N,Negrel S,Zhang Y,Magis D,Roux C,Hua X,Ding Z,Morisseau C,Tantillo DJ,Siegel JB,Hammock BD.  (2020)  Development of potent inhibitors of the human microsomal epoxide hydrolase.,  193  [PMID:32203787] [10.1016/j.ejmech.2020.112206]

Source