(2R,3S,4R,5R,6S)-5-amino-6-((1S,2R,3S,4R,6S)-4,6-diamino-2-((2S,3R,4S,5R)-5-((S)-1-aminoethyl)-3,4-dihydroxytetrahydrofuran-2-yloxy)-3-hydroxycyclohexyloxy)-2-((R)-1-hydroxyethyl)tetrahydro-2H-pyran-3,4-diol

ID: ALA4859688

PubChem CID: 164614264

Max Phase: Preclinical

Molecular Formula: C19H38N4O10

Molecular Weight: 482.53

Molecule Type: Unknown

Names and Identifiers

Canonical SMILES:  C[C@H](N)[C@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](N)C[C@H](N)[C@@H]2O[C@H]2O[C@H]([C@@H](C)O)[C@@H](O)[C@H](O)[C@H]2N)[C@H](O)[C@@H]1O

Standard InChI:  InChI=1S/C19H38N4O10/c1-4(20)14-12(28)13(29)19(30-14)33-17-9(25)6(21)3-7(22)16(17)32-18-8(23)10(26)11(27)15(31-18)5(2)24/h4-19,24-29H,3,20-23H2,1-2H3/t4-,5+,6+,7-,8+,9-,10+,11-,12-,13+,14+,15+,16-,17+,18+,19-/m0/s1

Standard InChI Key:  KJBRSTPUILEBDR-QIOMVVGSSA-N

Molfile:  

 
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M  END

Alternative Forms

1. Parent:

   

   ALA4859688

   ---

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Unknown

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 482.53

Molecular Weight (Monoisotopic): 482.2588

AlogP: -5.88

#Rotatable Bonds: 6

Polar Surface Area: 262.38

Molecular Species: BASE

HBA: 14

HBD: 10

#RO5 Violations: 2

HBA (Lipinski): 14

HBD (Lipinski): 14

#RO5 Violations (Lipinski): 2

CX Acidic pKa: 12.17

CX Basic pKa: 9.70

CX LogP: -5.60

CX LogD: -10.67

Aromatic Rings: ┄

Heavy Atoms: 33

QED Weighted: 0.17

Np Likeness Score: 1.36

References

1. Popadynec M, Baradaran-Heravi A, Alford B, Cameron SA, Clinch K, Mason JM, Rendle PM, Zubkova OV, Gan Z, Liu H, Rebollo O, Whitfield DM, Yan F, Roberge M, Powell DA..  (2021)  Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets.,  12  (9.0): [PMID:34531957] [10.1021/acsmedchemlett.1c00349]

Source

Source(1):

• Scientific Literature