5Z-(9S,11R,15S)-13-Oxa-16-phenoxy-propoxy]-9,11,15-trihydroxy-17,18,19,20-tetranor-5-prostadienoic acid

ID: ALA491475

Chembl Id: CHEMBL491475

PubChem CID: 44564519

Max Phase: Preclinical

Molecular Formula: C21H30O7

Molecular Weight: 394.46

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  O=C(O)CCC/C=C\C[C@@H]1[C@@H](OC[C@H](O)COc2ccccc2)[C@H](O)C[C@@H]1O

Standard InChI:  InChI=1S/C21H30O7/c22-15(13-27-16-8-4-3-5-9-16)14-28-21-17(18(23)12-19(21)24)10-6-1-2-7-11-20(25)26/h1,3-6,8-9,15,17-19,21-24H,2,7,10-14H2,(H,25,26)/b6-1-/t15-,17+,18+,19-,21-/m1/s1

Standard InChI Key:  HYMKBRFXEHNVOK-XKRIOCRBSA-N

Associated Targets(non-human)

PTGFR Prostanoid FP receptor (37 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptgfr Prostanoid FP receptor (188 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 394.46Molecular Weight (Monoisotopic): 394.1992AlogP: 1.75#Rotatable Bonds: 12
Polar Surface Area: 116.45Molecular Species: ACIDHBA: 6HBD: 4
#RO5 Violations: HBA (Lipinski): 7HBD (Lipinski): 4#RO5 Violations (Lipinski):
CX Acidic pKa: 4.22CX Basic pKa: CX LogP: 1.35CX LogD: -1.67
Aromatic Rings: 1Heavy Atoms: 28QED Weighted: 0.32Np Likeness Score: 1.11

References

1. Feng Z, Hellberg MR, Sharif NA, McLaughlin MA, Williams GW, Scott D, Wallace T..  (2009)  Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity.,  17  (2): [PMID:19101156] [10.1016/j.bmc.2008.11.070]

Source