Standard InChI: InChI=1S/C49H59ClN8O9S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)53-37(45-56-55-31(4)58(45)48)23-40(61)67-21-20-65-17-16-64-18-19-66-26-39(60)54-44(49(5,6)7)47(63)57-25-36(59)22-38(57)46(62)51-24-32-8-10-34(11-9-32)43-29(2)52-27-68-43/h8-15,27,36-38,44,59H,16-26H2,1-7H3,(H,51,62)(H,54,60)/t36-,37+,38+,44-/m1/s1
Standard InChI Key: HZTRWCKQNKXISW-PYNGZGNASA-N
Associated Targets(Human)
von Hippel-Lindau disease tumor suppressor/Bromodomain-containing protein 4 105 Activities
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von Hippel-Lindau disease tumor suppressor/Bromodomain-containing protein 3 16 Activities
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von Hippel-Lindau disease tumor suppressor/Bromodomain-containing protein 2 53 Activities
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MV4-11 7307 Activities
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CWR22R 2180 Activities
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Von Hippel-Lindau disease tumor suppressor 136 Activities
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Molecule Features
Natural Product: No
Oral: No
Chemical Probe: No
Parenteral: No
Molecule Type: Unknown
Topical: No
First In Class: No
Black Box: No
Chirality: No
Availability: No
Prodrug: No
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Properties
Molecular Weight: 1003.64
Molecular Weight (Monoisotopic): 1002.3535
AlogP:
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References
1.Klein VG, Bond AG, Craigon C, Lokey RS, Ciulli A.. (2021) Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity., 64 (24.0):[PMID:34881891][10.1021/acs.jmedchem.1c01496]
